Results 71 to 80 of about 324,915 (231)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Single‐Field Evolution Rule Governs the Dynamics of Representational Drift in Mouse Hippocampal Dorsal CA1 Region

Advanced Science
Hippocampal place codes change substantially across days, yet the mechanisms governing their temporal evolution remain incompletely understood. To quantitatively characterize this process, longitudinal one‐photon calcium imaging of dorsal CA1 neurons in ...
Cong Chen, Shuyang Yao, Sihui Cheng, Jiayi Tian, Ang Li, Yusen Yan, Xiang Zhang, Yuanjing Liu, Yumeng Wang, Qichen Cao, Chenglin Miao   +10 more
doaj   +1 more source

Knowledge-enhanced graph transformer with contrastive learning for drug-drug interaction prediction

Machine Learning with Applications
Background: Adverse drug-drug interactions (DDIs) remain a critical public health concern, responsible for approximately 125,000 deaths annually in the United States and accounting for nearly 30% of all adverse drug events.
Masoud Amiri, Bahador Makkiabadi
doaj   +1 more source

Tumour necrosis factor-α inhibitors for ankylosing spondylitis and non-radiographic axial spondyloarthritis: a systematic review and economic evaluation

Health Technology Assessment, 2016
Background: Tumour necrosis factor (TNF)-α inhibitors (anti-TNFs) are typically used when the inflammatory rheumatologic diseases ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-AxSpA) have not responded adequately to ...
Mark Corbett, Marta Soares, Gurleen Jhuti, Stephen Rice, Eldon Spackman, Eleftherios Sideris, Thirimon Moe-Byrne, Dave Fox, Helena Marzo-Ortega, Lesley Kay, Nerys Woolacott, Stephen Palmer   +11 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Exploratory mixed-methods analysis of the determinants of use of health research evidence among planning teams in Tanzania

BMJ Open
Introduction Achieving universal health coverage requires the use of health research evidence in decision-making; however, this remains understudied in lower and middle-income countries (LMICs) such as Tanzania.
Albino Kalolo, Pius Kagoma, Richard Mongi   +2 more
doaj   +1 more source

Application of integrated Bayesian modeling and Markov chain Monte Carlo methods to the conservation of a harvested species [PDF]

Animal Biodiversity and Conservation, 2004
When endeavoring to make informed decisions, conservation biologists must frequently contend with disparate sources of data and competing hypotheses about the likely impacts of proposed decisions on the resource status.
Fonnesbeck, C. J., Conroy, M. J.
doaj  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Conducting water-energy-food nexus studies: what, why, and how

Scientific Reports
The increasing pressure on resources and the persistent failure to address global malnutrition are evident challenges. A significant contributing factor is the decline in the quality of production resources, particularly water.
Ebrahim Farmandeh, Shahla Choobchian, Shobeir Karami   +2 more
doaj   +1 more source