Results 231 to 240 of about 2,962,676 (306)

Spray‐Dried Engineered Escherichia coli Whole‐Cell Biocatalysts Enable Cell Recycling and In Vivo α‐Ketoglutarate and NADPH Regeneration for Efficient Codeine Manufacture

Biotechnology and Bioengineering, EarlyView.
ABSTRACT A recombinant whole‐cell biocatalytic approach provides several advantages over isolated enzymes, such as improved enzyme stability, in vivo cofactor regeneration, and the facilitation of cascade reactions within a single cell. Whole‐cell biocatalysis has gained attention in medicinal opioid production, due to its technical and economic ...
Ali Jahanian, Carlos Horacio Luna‐Flores, Xu Li, Sally L. Gras, Robert E. Speight   +4 more
wiley   +1 more source

Pregnancy and kidney transplantation: optimized clinical and obstetric management to reduce maternal and perinatal complications. [PDF]

J Bras Nefrol
Santos ACM, Freitas RCM, Kahhale S, Francisco RPV, Galletta MAK.   +4 more
europepmc   +1 more source

Metabolic Flux Analysis Reveals Cell Line‐Specific Rewiring in CHO Cells Following TCA Cycle Intermediate Feeding for Bioprocess pH Control

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Chinese hamster ovary (CHO) cells are the leading host for recombinant therapeutic protein production in the biopharma industry. In this study, we investigated how feeding acidic forms of tricarboxylic acid (TCA) cycle intermediates—malic acid, succinic acid, and α‐ketoglutaric acid—affects cell culture performance and metabolism in two ...
Sarah A. Sacco, Kevin J. Ruiz‐Márquez, Rachel Moen, Irina Trenary, Xiaolin Zhang, Xiaowen Wang, Malik Padellan, Henry Lin, Jamey D. Young   +8 more
wiley   +1 more source

Progranulin deficiency in the brain activates an insulin signaling pathway that may promote neurodegeneration. [PDF]

iScience
Sajan MP, Aggarwal G, Hwang JJ, Smith DM, Cooper DR, Duncan MA, Hansen BC, Nguyen AD, Farese RV.   +8 more
europepmc   +1 more source

Ser médico, ser humano

Archivos Argentinos de Pediatria, 2016
openaire   +1 more source

Microbial Hydrolysates as Amino Acid Source in Cell Culture Media for Cellular Agriculture

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The high cost of cultivation media remains one of the barriers to the commercialization of cultivated meat. Current serum‐free media reduce reliance on fetal bovine serum but only achieve modest cost savings. Especially at larger scales (> 20 m3), pharmaceutical‐grade amino acids and recombinant proteins remain major cost drivers.
Jelle C. Hoek, Jean‐Marc Daran, Marieke E. Klijn, Marcel A. Vieira‐Lara   +3 more
wiley   +1 more source

Serine Acetyltransferase from <i>Pseudomonas aeruginosa</i>: Distinctive Features, Pleiotropic Roles, and Therapeutic Potential. [PDF]

Int J Mol Sci
Guggino F, Hijazi S, Martedì R, Buoli Comani V, D'Angelo JML, De Bei O, Annunziato G, Pieroni M, Costantino G, Bettati S, Marchetti M, Frangipani E, Campanini B.   +12 more
europepmc   +1 more source

From brush conformation to 3D Supraparticles: Programmable self‐assembly of polymer‐grafted nanoparticles in emulsion confinement

Bulletin of the Korean Chemical Society, EarlyView.
This review highlights how the conformational adaptability of polymer‐grafted nanoparticles drives their programmable self‐assembly within 3D emulsion droplets. By coupling brush thermodynamics with soft confinement, these dynamic building blocks form hierarchical supraparticles tailored for advanced plasmonics, compartmentalized catalysis, and stimuli‐
Hongseok Yun
wiley   +1 more source

Deciphering the regulatory mechanism of neural behavioral decisions through biogenic amine-mediated modulation of neural circuits in <i>Caenorhabditis elegans</i>. [PDF]

Front Syst Neurosci
Liu H, Shen Y, Peng D.
europepmc   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source