Results 41 to 50 of about 9,699,369 (280)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Regularizing deep networks using efficient layerwise adversarial training

, 2018
Adversarial training has been shown to regularize deep neural networks in addition to increasing their robustness to adversarial examples. However, its impact on very deep state of the art networks has not been fully investigated.
Chellappa, Rama, Jain, Arpit, Lim, Ser Nam, Sankaranarayanan, Swami   +3 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Influence of age on the occurrence of adverse events in rheumatic patients at the onset of biological treatment: data from the BIOBADASER III register

Arthritis Research & Therapy, 2020
Objectives To assess whether age, at the beginning of biologic treatment, is associated with the time a first adverse event (AE) appears in patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS), or psoriatic arthritis (PsA).
Paloma Vela, Carlos Sanchez-Piedra, Carolina Perez-Garcia, María C. Castro-Villegas, Mercedes Freire, Lourdes Mateo, Cesar Díaz-Torné, Cristina Bohorquez, Juan M. Blanco-Madrigal, Inmaculada Ros-Vilamajo, Silvia Gómez, Rocio Caño, Fernando Sánchez-Alonso, Federico Díaz-González, Juan J. Gómez-Reino   +14 more
doaj   +1 more source

The whole-body motor skills of children with autism spectrum disorder taking goal-directed actions in virtual reality

Frontiers in Psychology, 2023
Many symptoms of the autism spectrum disorder (ASD) are evident in early infancy, but ASD is usually diagnosed much later by procedures lacking objective measurements.
Maria Eleonora Minissi, Lucía Gómez-Zaragozá, Javier Marín-Morales, Fabrizia Mantovani, Marian Sirera, Luis Abad, Sergio Cervera-Torres, Soledad Gómez-García, Irene Alice Chicchi Giglioli, Mariano Alcañiz   +9 more
doaj   +1 more source

Ser japonês, ser nikkei, ser dekassegui

Revista de Antropologia da UFSCar, 2014
O •luxo transnacional de brasileiros para o Japão trouxe várias disrupções dentro das comunidades nikkei espalhadas pelo Brasil, mas, mais do que isso: contorce e dobra planos hierárquicos seculares. Ancorado na lógica familiar do ie por vários séculos e aliando-se à incorporação dessa lógica com a fabricação da cidadania japonesa, temos no processo ...
openaire   +2 more sources

Ser o no ser

Derechos en Acción, 2020
El estudio que aquí se presenta se basa en el análisis crítico de la sentencia que condenó a cadena perpetua Reina Maraz Bejarano (en adelante RM) por el delito de homicidio agravado por el vínculo, para referirme luego a la sentencia que la absolvió.
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source