Results 231 to 240 of about 543,604 (270)

Substrate Characterization of Mycobacterial Kinase PknG Revealing PknG‐KARS‐MAPK Phosphorylation Signaling Axis in Host

iMetaMed, EarlyView.
This study employed multi‐omics approaches to investigate the regulatory mechanism of Mycobacterium PknG on host cell processes. We found that host lysine‐tRNA ligase (KARS) is a potential substrate of PknG; and PknG can regulate the immune response by catalyzing the phosphorylation of KARS at T592 and T595 sites, affecting the phosphorylation level in
Nana Tian, Shuyu Xie, Yanqing Tang, Junjie Liang, Wenhan Zhu, Tianqi Liu, Yewen Sun, Yang Yang, Luoxi Zhang, Danfeng Wang, Chuyao Lin, Jinyu Jia, Minjia Tan, Jun‐Yu Xu   +13 more
wiley   +1 more source

Social determinants of health, the research we need. [PDF]

Biomedica
Álvarez-Dardet C, Pérez-Wilson P, Marcos-Marcos J.   +2 more
europepmc   +1 more source

Superior through‐plane thermal conductivity in carbon fibers/spherical graphene/epoxy laminated composites for low‐altitude aircrafts

InfoMat, EarlyView.
To address the low through‐plane thermal conductivity (λ⊥) of carbon fiber/epoxy composites, which poses thermal management challenges in the expanding low‐altitude economy, we incorporated spherical thermally reduced graphene (s‐TRG) as a bridging filler. This architectural design achieved a λ⊥ of 2.73 W m–1 K–1 at 10 wt% loading.
Shengyuan Gao, Hua Guo, Yongqiang Guo, Hua Qiu, Wei Gong, Junwei Gu   +5 more
wiley   +1 more source

[Proposal for Responsible Use of Generative Artificial Intelligence in Medical Practice]. [PDF]

Rev Neurol
Pérez Martínez DA.
europepmc   +1 more source

Engineering exosomal cargo loading via endogenous molecular pathways: Strategies to enhance therapeutic potential

Interdisciplinary Medicine, EarlyView.
This review illustrates how scientists engineer exosomes by hijacking the cell's own cargo‐sorting machinery. These strategies efficiently load therapeutic molecules into natural vesicles, creating powerful next‐generation drug delivery systems (Created with BioGDP.com).
Huanrong Zhu, Chenning Zhang, Shihan Ma, Zhanxue Xu, Cailing Liang, Fang Cheng, Hongbo Chen   +6 more
wiley   +1 more source

[XVII Post-ECTRIMS Meeting: Review of the New Developments Presented at the 2024 ECTRIMS Congress (I)]. [PDF]

Rev Neurol
Fernández Ó, Arés A, Agüera E, Aladro Y, Alonso A, Arroyo R, Brieva L, Calles C, Caminero AB, Castillo-Triviño T, Costa-Frossard L, Eichau S, Hernández MÁ, Landete L, Llaneza M, Llufriu S, Meca-Lallana JE, Meca-Lallana V, Moral E, Oreja-Guevara C, Prieto JM, Romero-Pinel L, Vilaseca A, Rodríguez-Antigüedad A.   +23 more
europepmc   +1 more source

Bioinorganic Site‐Specific Conjugation of Multi‐Arm Linkers to Create Pharmaceuticals With Targeting and Effector Functions

Journal of the Chinese Chemical Society, EarlyView.
This Account showcases a modular, multi‐arm linker platform that decouples payload loading from antibody conjugation. By leveraging a computationally designed ACPGHA zinc‐binding motif, we demonstrate the construction of homogeneous antibody‐drug conjugates and theranostic antibody‐radionuclide conjugates with high payload loading. The multi‐arm linker
Cédric Grauffel, Tse Wen Chang, Carmay Lim   +2 more
wiley   +1 more source

[Sexual and reproductive health among adolescent girls in protection and social reintegration programs in Chile: tensions between paternalism and bodily autonomy]. [PDF]

Salud Colect
González Aristegui D, Leal Fuentes I, Carstens Riveros C, Molina González T.   +3 more
europepmc   +1 more source

[Inflammatory and clinical markers predicting mortality in neonates under 1500 g]. [PDF]

Rev Med Inst Mex Seguro Soc
González AP, Acuña-Cenoz LI, Alcázar-Olaiz MD, Estevez-Alemán PF, Paque-Bautista C, Sosa-Bustamante GP.   +5 more
europepmc   +1 more source

Prevalence of resistance to macrolides and aminoglycosides in Mycobacterium avium, M. abscessus, and M. chelonae identified in the Laboratorio Nacional de Referencia of Colombia from 2018 to 2022 [PDF]

Biomedica
Llerena C, Valbuena YA, Zabaleta AP, García AN.   +3 more
europepmc   +1 more source