Results 41 to 50 of about 1,827,067 (252)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Interculturalidad, multiculturalidad o localismo: un modelo para la LIJ catalana [PDF]

, 2010
La literatura infantil y juvenil catalana muestra determinadas peculiaridades por sus circunstancias sociales que la hacen menos sensible a determinados cambios como pueda ser la globalización o la introducción de la interculturalidad.
Mínguez López, Xavier
core  

Spectral Templates from Multicolor Redshift Surveys [PDF]

, 1999
Understanding how the physical properties of galaxies (e.g. their spectral type or age) evolve as a function of redshift relies on having an accurate representation of galaxy spectral energy distributions.
Alexander S. Szalay, Andrew J. Connolly, Baum W. A., Everson R., Hogg D. W., István Csabai, Karhunen H., Koo D. C., Mark Dickinson, Tamás Budavári   +9 more
core   +4 more sources

Una nueva escuela para nuevas vidas: Territorios sensibles estudiantiles que narran corporalmente las violencias del conflicto armado colombiano

Cuerpo Cultura y Movimiento
En este artículo se comparten reflexiones vinculadas a los postulados teóricos de una investigación doctoral en curso, que establece los modos en los que una nueva escuela posible puede gestarse alrededor del ser, como forma de contrarrestar las ...
Irene Montoya-Rivera, Ana Sabrina Mora
semanticscholar   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Estudio del efecto del óxido en el comportamiento en rotura de la vaina de barra combustible [PDF]

, 2011
La capa exterior de óxido en la vaina de combustible nuclear es un factor clave en el estudio de su comportamiento en rotura. En esta ponencia se utiliza el ensayo de compresión diametral (RCT) para estudiar el comportamiento en rotura de vainas oxidadas.
Martín Rengel, Miguel Ángel, Ruiz Hervías, Jesús, Torres, E.   +2 more
core  

Combining tower mixing ratio and community model data to estimate regional-scale net ecosystem carbon exchange by boundary layer inversion over 4 flux towers in the U.S.A. [PDF]

, 2011
We evaluated an idealized boundary layer (BL) model with simple parameterizations using vertical transport information from community model outputs (NCAR/NCEP Reanalysis and ECMWF Interim Analysis) to estimate regional-scale net CO2 fluxes from 2002 to ...
Dang, Xuerui, Ehleringer, James R., Hollinger, David Y., Lai, Chun-Ta, Munger, J. William, Owensby, Clenton, Schauer, Andrew J., Xiao, Jingfeng   +7 more
core   +2 more sources

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Induced sputum versus exhaled nitric oxide for the evaluation of airway inflammation in allergic paediatric asthma patients treated with omalizumab [PDF]

, 2013
Our purpose is to determine the inflammatory changes in the airways of allergic paediatric asthma patients treated with omalizumab, measured by the percentage ofEl nostre objectiu és determinar els canvis inflamatoris en la via aèria de pacients ...
Domingo Miró, Xavier, Universitat Autònoma de Barcelona. Departament de Medicina, Universitat Autònoma de Barcelona. Facultat de Medicina   +2 more
core   +1 more source