Results 41 to 50 of about 543,604 (270)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Provocando encuentros con el arte por las fisuras de la nutrición estética y mediación cultural
Pensamiento Palabra y Obra, 2019 Este artículo presenta dos conceptos: nutrición estética y mediación cultural, que fundamentan una metodología de trabajo centrada en la formación de educadores.
Miriam Celeste Martins
doaj +1 more source
Biasing MCTS with Features for General Games [PDF]
, 2019 This paper proposes using a linear function approximator, rather than a deep neural network (DNN), to bias a Monte Carlo tree search (MCTS) player for general games. This is unlikely to match the potential raw playing strength of DNNs, but has advantages
Browne, Cameron +2 more
core +3 more sources
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Interculturalidad, multiculturalidad o localismo: un modelo para la LIJ catalana [PDF]
, 2010 La literatura infantil y juvenil catalana muestra determinadas peculiaridades por sus circunstancias sociales que la hacen menos sensible a determinados cambios como pueda ser la globalización o la introducción de la interculturalidad.
Mínguez López, Xavier
core
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Stem-root flow effect on soil–atmosphere interactions and uncertainty assessments [PDF]
, 2015 . Soil water can rapidly enter deeper layers via vertical redistribution of soil water through the stem–root flow mechanism. This study develops the stem–root flow parameterization scheme and coupled this scheme with the Simplified Simple Biosphere model
Chen, J-P, Kuo, T-H, Xue, Y
core +2 more sources
FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source
Persona y Sociedad, 2007 Al referirse al tradicional reparto de un sistema de las artes, Heidegger pareciera dejar intocada sólo a la música. En términos de referencia temática ella aparece en su mayor extensión subordinada a la paulatina confrontación de Nietzsche con Wagner ...
Cristóbal Durán
doaj +1 more source
PRECARIEDAD Y ABYECCIÓN EN WILSON PACCHA
INDEX Revista de Arte Contemporáneo, 2020 El presente análisis aborda la práctica artística de Wilson Paccha y su estrategia para manipular las normas del arte desde la marginalidad, insertando lo imposible de ser nombrado al arte contemporáneo del contexto quiteño, pero también me interesa ...
Franciné Córdova
doaj +1 more source