Directed evolution of enzymes at the crossroads of tradition and innovation
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Long-Term Clinical and Radiologic Evaluation of Micronized Acellular Dermal Matrix-Assisted Reconstruction in Diabetes-Related and Traumatic Foot Wounds With Bone Defects. [PDF]
Nam HJ, Bae J, Kim SY, Choi HJ.
europepmc +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
Effectiveness of Serial Membrane Sweeping and Stretching at Term for the Induction of Labour. [PDF]
Ete G +6 more
europepmc +1 more source
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose +9 more
wiley +1 more source
Psychological contract, psychological capital, career plateau, and job embeddedness among early-career nurses: a serial mediation model. [PDF]
Wang X, Qin Y, Mao Q, Wang J.
europepmc +1 more source
Social media addiction and social anxiety among college students: the serial mediating roles of alienation, self-focused attention, and fear of negative evaluation. [PDF]
Xu X, Fang H.
europepmc +1 more source
Positive and negative maternal mental health demonstrate distinct pathways to childhood depression. [PDF]
Huang P +16 more
europepmc +1 more source
Further Contributions to the Problem of Serial Correlation
openaire +3 more sources

