Results 191 to 200 of about 25,661 (263)

PANX2 Suppresses Lung Adenocarcinoma Progression by Inducing Disulfidptosis and Enhancing Antitumor Immunity

Advanced Science, EarlyView.
ABSTRACT Lung adenocarcinoma (LUAD) remains a leading cause of cancer mortality with limited therapeutic options. Disulfidptosis, a novel cell death modality driven by disulfide stress, represents a promising target, yet its regulation in LUAD is poorly defined. Here, we identify Pannexin 2 (PANX2) as a tumor suppressor in LUAD.
Yi Chen, Zhao‐Yu Liu, Gao‐Wen Qu, Run‐Hao Zeng, Wen‐Xia Yao, Yong‐Bing Zhou, Xue Liang, Yu‐Xiong Lai   +7 more
wiley   +1 more source

Age-related differences and common pathways of lymphocyte subsets in sepsis: a comparative review of elderly and pediatric patients. [PDF]

Cell Death Dis
Wang X, Huang Q, Zuo Z, Wang Z, Zhang L, Qian Z.   +5 more
europepmc   +1 more source

Lactoferrin Deficiency During Lactation Causes Adult Obesity‐Related Metabolic Disease Through Persistent Adipose Dysfunction Driven by Impaired Adipocyte Development

Advanced Science, EarlyView.
Lactational lactoferrin deficiency exerts lasting effects on epididymal adipose tissue development from lactation into adulthood: it impairs adipocyte hyperplasia and induces pathological hypertrophy, resulting in lower body weight yet exacerbated metabolic dysfunction under a high‐fat diet in adulthood.
Qin An, Yunxia Zou, Wenli Wang, Zhimei Cheng, Zhuoxing Zhang, Ruwei Liu, Xiong Wang, Kunlun Huang, Fangrong Ding, Yunping Dai, Qingyong Meng, Yali Zhang   +11 more
wiley   +1 more source

Temporal dynamics of fibroblast activation after acute myocardial infarction: Imaging and image-guided modulation

Thackeray J, Mayola MF, Strunk M, Hess A, Fischer J, Polten R, Willmann M, Diekmann J, Al-Bazaz S, Ross T, Leuschner F, Wienecke L, Schambach A, Morgan M, Bengel F.   +14 more
europepmc   +1 more source

Adaptive-like CAR-iPSC-CD4⁺ T cells outperform CD8⁺ counterparts in sustained ALL control. [PDF]

Inflamm Regen
Guo Q, Zhang C, Wang B, Iriguchi S, Ishikawa A, Minagawa A, Ishii T, Kawai Y, Kaneko S.   +8 more
europepmc   +1 more source

BCMA‐Engineered Dendritic Cell‐Derived Exosomes as Bi‐Functional Therapeutics Orchestrating Cytokine Sequestration and Immune Activation for Multiple Myeloma

Advanced Science, EarlyView.
A dual‐function cell‐free therapeutic based on DC2.4 cell‐derived exosomes engineered to display BCMA. (Left) Soluble Ligand Sequestration (Decoy Function): DB Exo act as molecular decoys that predominantly sequester soluble APRIL with partial BAFF attenuation, effectively disrupting the NF‐κB survival signaling axis and suppressing myeloma cell ...
Yuqing Zeng, Chao He, Zhibin He, Hongbo Chen, Fang Cheng, Yongjiang Zheng   +5 more
wiley   +1 more source

Lineage-Specific Chimerism Analysis After Allogeneic Hematopoietic Cell Transplantation in Patients with Myeloid Neoplasms: Current Evidence and Considerations in the Post-Transplant Cyclophosphamide Setting. [PDF]

Biomedicines
Zaucha JM, Zaucha JM, Piekarska A.
europepmc   +1 more source

Supramolecular Assembly of Stepped‐Persistent ROS Nanogenerator for Sustained Tumor Immunotherapy

Advanced Science, EarlyView.
ROS catalytic systems often fail to achieve both effective tumor elimination and persistent immune activation due to their monotonous ROS production profiles. A stepped‐persistent ROS nanogenerator was developed by supramolecularly assembling multiple ROS generation modules within a nanofiber structure to simultaneously extend ROS generation duration ...
Zhenqiang Wang, Ming Qin, Wenjing Lai, Shiwen Chen, Fengling Wang, Dandan Xie, Maohua Chen, Changpeng Hu, Kui Wang, Rong Zhang, Guobing Li   +10 more
wiley   +1 more source

An innovative treatment for lung cancer using gene-engineered human-induced pluripotent stem cell-derived natural killer cells. [PDF]

Cancer Immunol Immunother
Sato Y, Goto K, Yagishita S, Miyata K, Uesugi N, Torisawa YS, Naritomi Y, Takahashi R, Sho R, Takeno Y, Kurachi K, Yamada M, Higashi Y, Kimura H, Hamada A, Nishigaki F, Tamura K.   +16 more
europepmc   +1 more source

Agent-based modeling of cellular dynamics in adoptive cell therapy. [PDF]

Commun Biol
Wang Y, Casarin S, Daher M, Mohanty V, Dede M, Shanley M, Dondossola E, La Posta L, Başar R, Rezvani K, Chen K.   +10 more
europepmc   +1 more source