Results 191 to 200 of about 1,591 (255)

Noninvasive Characterization of Tumor Heterogeneity in HNSCC: From Clinical Utility to Biological Correlates

Advanced Science, EarlyView.
This study establishes a CT‐based radiomics framework to quantify intratumoral heterogeneity (ITH) in HNSCC. Using unsupervised clustering, tumor ROIs and VOIs are analyzed to calculate 2D/3D ITH scores. The score shows strong predictive value for prognosis and immunotherapy response, and is associated with tumor metabolism and immune microenvironment,
Xinwei Chen, Rui Liu, Yuan Zhou, Yin Xiao, Chengmin Feng, Lin Chen, Yanshi Li, Mengna Wang, Zhaobo Cheng, Yuxi Luo, Long Liu, Lijing Niu, Yue Xiang, Juan Peng, Guohua Hu, Min Pan   +15 more
wiley   +1 more source

Overcoming T cell tolerance to tumor self-antigens through catch-bond engineering. [PDF]

Science
Chen X, Mao Z, Kolawole EM, Persechino M, Jude KM, Ogishi M, Mo KC, McLaughlin J, Cheng D, Xiang X, Yang X, Gee C, Liu S, Yang A, Obenaus M, Wang N, Noguchi M, Stoyanova T, Lee JK, Good Z, Latorraca NR, Evavold BD, Witte ON, Garcia KC.   +23 more
europepmc   +1 more source

NAT10‐Mediated ac4C Modification of circANKRD12 Reprograms the Tumor Microenvironment

Advanced Science, EarlyView.
NAT10‐dependent acetylation of circANKRD12 drives translation of the circANKRD12_354aa protein, which binds HDAC2 to stabilize c‐Myc via deubiquitination, promoting multiple myeloma (MM) cell proliferation. Concurrently, the circANKRD12‐HDAC2 axis suppresses H3ac‐mediated transcription of IFN‐γ, TNF‐α, and GZMB in NK cells, leading to NK cell ...
Jiale Zhang, Hui Shi, Chen Wang, Zihao Liu, Lianxin Zhou, Xinyu Lv, Mengjie Guo, Ye Yang, Chunyan Gu   +8 more
wiley   +1 more source

Modular Droplet-Based Microfluidic Platform for Functional Phenotypic Screening of Natural Killer Cells. [PDF]

Small Methods
Aubermann F, Seneca S, Hofman T, Garcés-Lázaro I, Ajmail K, Daubner K, Cerwenka A, Platzman I, Spatz JP.   +8 more
europepmc   +1 more source

A chemostat-based model for growing bacterial biofilms. [PDF]

Microbiol Spectr
Spagnolo F, Caballero I, Goldblatt A, Loccisano MJ, Mahe MI, Mejia Y, Melvani N, Nagel A, Stanciu A, Kannoly S, Dennehy JJ, Trujillo M.   +11 more
europepmc   +1 more source

A high-parameter spectral cytometry protocol for immune subset and functional characterization of cryopreserved human blood with 49 biomarkers. [PDF]

STAR Protoc
Wright AP, Lindaman M, Huang E, Coussens LM, Poissonnier A.   +4 more
europepmc   +1 more source

Evil's Anatomy: Structural Correlates of Violent Behavior. [PDF]

Cureus
Moreno-Jiménez S, Olguín Gómez M, Quiñones Nájera PM, Carro Gallegos AJ, Salazar Pigeon A, Ballesteros Herrera D, Flores-Vázquez F, Alegría Loyola MA.   +7 more
europepmc   +1 more source

Canada's Medical Assistance in Dying System can Enable Healthcare Serial Killing. [PDF]

HEC Forum
Lyon C.
europepmc   +1 more source