Results 31 to 40 of about 1,591 (255)
Gain or Pain: Hedonism in Serial Femicide Fiction– A Psycho-social Critique [PDF]
مجلة الدراسات الإنسانية والأدبيةFemicide, a significant issue throughout history, is often understudied in literature. Scrutinizing human rights reports on the horrific acts of violence against women reveals that women have constituted a major part of gender-based violence and serial ...
Gehan M. Anwar Deeb
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Typological approach features in the investigation of serial sexual crimes
Психология и право, 2020 The article presents the results of testing the typology of serial sexual killers developed by O.D. Sitkovskaya and L.P. Konysheva, on the materials of criminal cases on detected serial crimes of a sexual nature.
Dvoryanchikov N.V., Zhuravleva E.R.
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Designed improvement to T-cell immunotherapy by multidimensional single cell profiling
Journal for ImmunoTherapy of Cancer, 2021 Background Adoptive cell therapy based on the infusion of chimeric antigen receptor (CAR) T cells has shown remarkable efficacy for the treatment of hematologic malignancies.
Navin Varadarajan +11 more
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FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
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“Rîmaru” – A Family of Serial Killers
Erdélyi JogéletBetween 1970 and 1971, Ion Rîmaru, a 25-year-old university student, committed a number of brutal murders, attempted murders, rapes, and attempted rapes in Bucharest.
Hunor Kádár
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Regulation of CD19 CAR-T cell activation based on an engineered downstream transcription factor
Molecular Therapy: Oncolytics, 2023 CAR-T cells present a highly effective therapeutic option for several malignant diseases, based on their ability to recognize the selected tumor surface marker in an MHC-independent manner. This triggers cell activation and cytokine production, resulting
Duško Lainšček +5 more
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Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source