Results 121 to 130 of about 1,081,091 (282)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

NKCC1: A key regulator of glioblastoma progression

open access: yesMolecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen   +5 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Does stimulus order affect central tendency and serial dependence in vestibular path integration?

open access: yesiScience
Summary: Reproduction of perceived stimuli, such as distances or durations, is shaped by two biases: central tendency, where reproductions are biased toward the mean of the stimulus distribution, and serial dependence, where the reproduction of the ...
Sophie C.M.J. Willemsen   +4 more
doaj   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

Noun Sequence Statistics Affect Serial Recall and Order Recognition Memory

open access: yesOpen Mind, 2023
Steven C. Schwering   +1 more
doaj   +1 more source

Forming the intermodal system of freight transportation on the east of Ukraine [PDF]

open access: yesTransport Problems, 2012
In this work the method of volumetric-calendar planning and production schedule drafting- the network planning - have been considered for the case, which is related to serial or serial-parallel execution of certain works and operations in order to ...
Aleksander GOLUBENKO   +2 more
doaj  

Object oriented execution model (OOM) [PDF]

open access: yes, 2011
This paper considers implementing the Object Oriented Programming Model directly in the hardware to serve as a base to exploit object-level parallelism, speculation and heterogeneous computing.
Cristal Kestelman, Adrián   +5 more
core  

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