Results 161 to 170 of about 9,366 (302)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Dosimetric and Radiobiological Comparison of Three-Dimensional Conformal Radiotherapy and Helical Tomotherapy in Whole Pelvic Radiotherapy of Prostate Cancer Patients. [PDF]

J Biomed Phys Eng
Mirzaeiyan M, Akhavan A, Amouheidari A, Adibi A, Hemati S, Etehadtavakol M, Khanahmad H, Shokrani P.   +7 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Use of NTCP metrics to identify unbalanced levels of dose trade-off between left lung and heart in lung cancer radiotherapy. [PDF]

J Appl Clin Med Phys
Komisopoulos G, Mavroidis P, Simopoulou F, Kyrgias G, Pant K, Roussakis Y, Theodorou K.   +6 more
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

NTCP Modeling and Dose-Volume Correlations of Significant Hematocrit Drop 3 Months After Prostate Radiation Therapy. [PDF]

Adv Radiat Oncol
Papanikolaou P, Swanson G, Stathakis S, Mavroidis P.   +3 more
europepmc   +1 more source

The earliest Pleistocene record of a large-bodied hominin from the Levant supports two out-of-Africa dispersal events. [PDF]

Sci Rep, 2022
Barash A, Belmaker M, Bastir M, Soudack M, O'Brien HD, Woodward H, Prendergast A, Barzilai O, Been E.   +8 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

The evolution of human-type consciousness - a by-product of mammalian innovation mechanism - a preliminary hypothesis. [PDF]

Front Psychol
Ben Zvi U.
europepmc   +1 more source

Serial homicide [PDF]

BMJ, 1996
openaire   +2 more sources