Digital twins to accelerate target identification and drug development for immune‐mediated disorders
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Evaluation of Tumor Control and Normal Tissue Complication Probabilities in Patients Receiving Comprehensive Nodal Irradiation for Left-Sided Breast Cancer. [PDF]
Flores-Balcázar CH, Urías-Arce DM.
europepmc +1 more source
National Technology Validation and Implementation Collaborative (NTVIC) policies and procedures for Forensic Investigative Genetic Genealogy (FIGG). [PDF]
Wickenheiser RA +7 more
europepmc +1 more source
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani +6 more
wiley +1 more source
Perceptual similarity and clustering in braille letter recognition. [PDF]
Özkan ZG, Baciero A, Perea M, Gómez P.
europepmc +1 more source
Positive Parenting, Prosocial Behavior, Meaning in Life, and Subjective Well-being in Adolescents: a Parallel and Serial Mediation Analysis [PDF]
Gökmen Arslan
openalex +1 more source
Physiologic serial changes in the visual appearance of urine samples from individual pet guinea pigs (Cavia porcellus) [PDF]
Mette Lybek Rueloekke +2 more
openalex +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Dementia as a Critical Lens on the Role of Narrative in Medical Training and Practice. [PDF]
Lamb EG, Wohlmann A.
europepmc +1 more source
Automatic and Serial Monitoring of Auditory Evoked Brain-stem Responses
Masaru Sasaki +7 more
openalex +2 more sources

