ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Herbicidal and Antibacterial Secondary Metabolites Isolated from the Nicotiana tabacum-Derived Endophytic Fungus Aspergillus japonicus TE-739D. [PDF]
Plants (Basel)Wang H, Yuan X, Huang X, Zhang P, Gu G.
europepmc +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Maximizing genetic gain over multiple generations with quantitative trait locus selection and control of inbreeding [PDF]
, 2004 Dekkers, J.C.M. +3 more
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
The impact of anxiety on gait impairments in Parkinson's disease: insights from sensor-based gait analysis. [PDF]
J Neuroeng RehabilZhang X +8 more
europepmc +1 more source
Immaculate catalogues, indexes and monsters too…: David E. Bennett reports on the three-day residential CILIP Cataloguing and Indexing Group Annual Conference, University of East Anglia, Norwich, UK, 13-15 September 2006. [PDF]
, 2006 Bennett, David
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source