The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
11 Essays on Societal Transformation: The Most Important Challenge Facing Humanity
Cadmus, 2021 Societal transformation can be framed up by starting from the present and moving forward or going to the endpoint and looking back. Incremental improvements to fundamentally flawed human systems will not work, especially in our limited time frame.
Frank Dixon
doaj
University students’ mental construction when learning the Convergence of a Series concept
Pythagoras, 2020 This article uses action-process-object-schema theory to study the mental constructions about the limit of series during a Calculus 1 course at a university. The researchers also used the theory’s teaching methodology to teach the topic.
Conilius J. Chagwia +2 more
doaj +1 more source
Concerning the discussion about the Bug series of the Middle Bug (Ukrainian shield)
Геофизический журнал, 2023 The materials of several articles and reports published in 2022 by the authors of this work and V.P. Kirilyuk (Kirilyuk, 2022 a,b), who discussed the structure and stratigraphy of the Вug area granulite complex of the Ukrainian Shield.
O.B. Gintov +3 more
doaj +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Brain‐responsive corticothalamic stimulation in the pulvinar nucleus for the treatment of regional neocortical epilepsy: A case series [PDF]
, 2021 David E. Burdette +3 more
openalex +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Anomaly Detection Using a Sliding Window Technique and Data Imputation with Machine Learning for Hydrological Time Series [PDF]
, 2021 Lattawit Kulanuwat +6 more
openalex +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source