Results 41 to 50 of about 11,946,791 (292)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Two Degree of Freedom Resonant Structure for Robust Current Control and Active Power Filtering [PDF]

, 2005
This paper introduces a novel two degree of freedom resonant control structure for current control in a stationary reference frame in one- or three-phase power electronics systems. The main focus is put on the design of the controller for robust tracking
N. Bajcinca, D. Naunin, Naunin, Dietrich, Bajcinca, Naim   +3 more
core   +1 more source

A Grid Connected Photovoltaic Generation System With Compensation Of Current Harmonics And Voltage Sags

Eletrônica de Potência, 2006
This paper presents a system that provides photovoltaic generation as well as the ability to compensate current harmonics and voltage sags. The system can be controlled for current harmonics and reactive power compensation simultaneously by using a ...
Marcelo Cabral Cavalcanti, Gustavo Medeiros de Souza Azevedo, Bruno de Aguiar Amaral, Francisco de Assis dos Santos Neves, Davi Carvalho Moreira, Kleber Carneiro de Oliveira   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dual-Band Tunable Recursive Active Filter [PDF]

, 2011
This letter presents a novel recursive active filter topology that provides dual-band performance, with independent tuning capability in both bands. The dual-band operation is achieved by using two independent feedback lines.
García Pérez, Oscar Alberto, Aznar Ballesta, Francisco, Daniel Segovia-Vargas, Vicente Gonzalez-Posadas, Francisco Aznar-Ballesta, Segovia Vargas, Daniel, Oscar Garcia-Perez, González Posadas, Vicente   +7 more
core   +1 more source

Hybrid Filters To Damp Harmonic Resonance In Power Transmission Systems

Eletrônica de Potência, 2006
Problems related to harmonic propagation in transmission systems have been noticed in the last years. Passive filters, commonly used to attenuate noncharacteristic harmonics in HVDC systems, stay at risk of disconnection from the system due to ...
Lucas F. Encarnação, Alexandre G. Merçon, Hélio H. de Almeida, Emanuel L. van Emmerik, Maurício Aredes   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

General Energy Filters for Power Smoothing, Tracking and Processing Using Energy Storage

IEEE Access, 2017
In the signal processing, active signal filters are commonly used to filter out the zero-average high-frequency components of a signal. In the power system, the power filters are used to filter and control the harmonics in voltages and current waveforms ...
Zuanhong Yan, Xiao-Ping Zhang
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source