Results 241 to 250 of about 8,556,345 (307)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem   +9 more
wiley   +1 more source

Discovery of Novel Ligands for the Treatment of Cryptococcus neoformans Infection. [PDF]

open access: yesArch Pharm (Weinheim)
Rocha T   +6 more
europepmc   +1 more source

What Is in a Structure? Cell Permeability and Solubility of Series of Macrocycles and Linear Matched Pairs. [PDF]

open access: yesJ Med Chem
Tyagi M   +13 more
europepmc   +1 more source

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