Results 351 to 360 of about 358,313 (362)
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Cysteine and serine proteases in gastric cancer
Cancer, 1995Cysteine proteases (cathepsin B [CATB] and cathepsin L [CATL]), the serine protease urokinase-type plasminogen activator (UPA), and plasminogen activator inhibitor type-1 (PAI-1) are thought to play an important part in cancer invasion and metastasis.
PLEBANI, MARIO +10 more
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Neutral serine proteases of neutrophils
Immunological Reviews, 2016SummaryNeutrophil serine proteases (NSPs) exercise tissue‐degrading and microbial‐killing effects. The spectrum of NSP‐mediated functions grows continuously, not least because of methodological progress. Sensitive and specific FRET substrates were developed to study the proteolytic activity of each NSP member. Advanced biochemical methods are beginning
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Is histoaspartic protease a serine protease with a pepsin‐like fold?
Proteins: Structure, Function, and Bioinformatics, 2004AbstractThe primary structure of the so‐called histoaspartic protease from Plasmodium falciparum has a very high percentage of identity and homology with the pepsin‐like enzyme plasmepsin II. A homology modeling approach was used to calculate the three‐dimensional structure of the enzyme.
M. E. Popov +4 more
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DEFECTS IN SERINE PROTEASE INHIBITORS [PDF]
Thrombosis and Haemostasis, 1987 Several serine protease inhibitorsof plasma inhibit the activated coagulation enzymes but only antithrombin III(AT-III)and heparin cofactor II (HC-II) are implicated in the pathogenesisof the familial thrombosis. Since thefirst publication (1965) many thrombophilic families with reduced AT-III synthesis have been investigated. These studies have proved
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Flexibility in the specificity site of serine proteases
Biochemistry, 1976The statistical availability of tryptophan and tyrosine residues with one ring face fully exposed to solvent was examined for two serine proteases and their derivatives by investigating the formation of charge transfer (CT) complexes between the aromatic donor residues of the protein and the acceptor 1-methylnicotinamide chloride.
Carol R. Coan +2 more
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Natural Proteinaceous Inhibitors of Serine Proteases
Current Pharmaceutical Design, 2012The deregulated proteolysis is associated with various diseases in humans. Proteases are commonly regarded as the therapeutic targets. Almost one-third of all proteolytic enzymes in humans are serine proteases. This work provides a brief characteristic of the proteinaceous natural inhibitors, mostly of serine proteases.
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ChemInform Abstract: Serine Proteases Inhibiting Cyanopeptides
ChemInform, 2000AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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Subtilases: Subtilisin-Like Serine Proteases
1996Subtilases are members of the family of subtilisin-like serine proteases. Over 70 subtilases are presently known, more than 60 of which with their complete amino acid sequence. In this update, details of more than 20 new subtilases discovered recently are summarized, and their sequences included in a multiple sequence alignment table.
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