Results 111 to 120 of about 1,302,007 (304)
iLABMED, EarlyView.A 65‐year‐old patient developed acute hemolytic transfusion reaction (AHTR) after receiving P1‐positive red blood cells. The causative anti‐P1 antibody was detectable only at 4°C, evading routine 37°C pre‐transfusion screening. This case highlights that in patients with a repeated transfusion history, dual‐temperature serological testing (37°C and 4°C)
Ke Song +6 more
wiley +1 more source
Gene expression signatures from single‐cell transcriptomics predict Sjögren's syndrome
iMetaOmics, EarlyView.A machine learning‐based 12‐gene signature (SjS.Sig) was developed from scRNA‐seq data of PBMCs from Sjögren's syndrome patients. The model was validated using bulk RNA‐seq datasets and further confirmed through flow cytometry and qPCR analysis in an independent clinical cohort, demonstrating robust diagnostic potential.
Shumin Cheng +20 more
wiley +1 more source
Interdisciplinary Medicine, EarlyView.Prospective multi‐site cohorts, multi‐omics profiling, and computational analysis may help identify biomarker patterns across clinical settings in IBD and superimposed infections. With further mechanistic and clinical validation, these signals could support the development of practical multi‐analyte tools for more precise diagnosis and management ...
Ziyu Yang +7 more
wiley +1 more source
Journal of Clinical Laboratory Analysis, EarlyView.The assay exploited a multiparametric and fully automated device applied to CHORUS EVO to validate that the CHORUS Macroarray Liver Diseases kit is a novel procedure for detecting autoantibodies of AIH and PBC. The assay resulted as linear, accurate, sensitive, specific, and able to distinguish between PBC and AIH.
Luigi Raganelli +14 more
wiley +1 more source
Journal of Clinical Laboratory Analysis, EarlyView.Naganishia diffluens, a rare non‐neoformans cryptococcal species, was identified by PCR sequencing as the causative agent of oral cryptococcosis in a 31‐year‐old Iranian man with β‐thalassemia. This case represents the first documented instance of oral infection by N.
Zahra Yahyazadeh +13 more
wiley +1 more source
Journal of Clinical Laboratory Analysis, EarlyView.This investigation was conducted in two phases. Phase I involved the classification and clinical profiling of AC‐30. In Phase II, quantitative image analysis was performed to explore its associations with clinical parameters. ABSTRACT Background The International Consensus on ANA Patterns (ICAP) recently codified the AC‐30 nuclear pattern ...
Changmeng Wu +5 more
wiley +1 more source
Journal of Clinical Laboratory Analysis, EarlyView.Exploring the application of urea dissociation treatment to reduce the false‐positive rate of ELISA for syphilis detection. From January 2023 to January 2024, seven false‐positive syphilis samples were collected from Xi'an Regional Medical Laboratory Centre as the experimental group, five positive specimens as the control group, and five negative ...
Jiao Wang, Bin Li, Haodi Li, Xucai Dong
wiley +1 more source
Characterization of Pulmonary Functional Abnormalities in Systemic Sclerosis Using Xenon MRI
Journal of Magnetic Resonance Imaging, EarlyView.ABSTRACT Background Xenon MRI is increasingly used to evaluate patients with interstitial lung disease (ILD) and pulmonary hypertension (PH), both of which are common manifestations of systemic sclerosis (SSc). As such, Xe‐MRI may be suited to interrogate lung function impairment in SSc.
Dawson Shaver +11 more
wiley +1 more source
Borrelia and Genital Lichen Sclerosus: A Critical Review of the Evidence
JEADV Clinical Practice, EarlyView.ABSTRACT Background Lichen sclerosus (LSc) is a chronic inflammatory dermatosis that primarily affects the genitalia. Growing evidence supports chronic occlusive urine exposure as the principal pathogenic driver, though other mechanisms, including mechanical irritation, hormonal influences, autoimmunity, and infection, have been proposed.
Liang Zhi Wong +4 more
wiley +1 more source