AAV's widespread application is currently confronting critical challenges. This study established a systematic framework of ‘natural discovery–evolutionary analysis–functional optimization’, providing a new paradigm for the development of next‐generation AAV vectors with clinical‐grade tissue specificity, low immunogenicity, and cross‐species ...
Liyu Zhu +11 more
wiley +1 more source
Canine Serology as Adjunct to Human Lyme Disease Surveillance
To better define areas of human Lyme disease risk, we compared US surveillance data with published data on the seroprevalence of Borrelia burgdorferi antibodies among domestic dogs.
Paul S. Mead +2 more
doaj +1 more source
SARS-CoV-2 exposure, symptoms and seroprevalence in healthcare workers in Sweden
Healthcare workers may be at higher risk of SARS-CoV-2 infection than the general population. Here, the authors report 19% seroprevalence of SARS-CoV-2 antibodies among 2,149 employees in a Swedish hospital.
Ann-Sofie Rudberg +23 more
doaj +1 more source
Surgical management of recurrent oesophageal obstruction in a yearling Saddlebred filly
Summary This case report describes the diagnostic approach and surgical management of a yearling Saddlebred filly with recurrent oesophageal obstruction, likely caused by an acquired extraluminal oesophageal stricture. The filly initially presented with repeated episodes of oesophageal obstruction, which were resolved with sedation and nasogastric ...
K. M. Andrews +4 more
wiley +1 more source
Mycoplasma gallisepticum (MG) infection is considered as one of the significant problems for the poultry industry in Bangladesh. Therefore, this study was to determine the seroprevalence of MG in poultry (layer, broiler, and Sonali) and the ...
Mirza Mienur Meher +3 more
doaj +1 more source
Seroprevalence of Dengue and Chikungunya Virus Antibodies, French Polynesia, 2014–2015
We investigated dengue and chikungunya virus antibody seroprevalence in French Polynesia during 2014–2015. Dengue virus seroprevalence was ≈60% among schoolchildren and >83% among the general population; chikungunya virus seroprevalence was
Maite Aubry +18 more
doaj +1 more source
Human parvovirus B19 and blood product safety. A tale of twenty years of improvements [PDF]
Parvovirus B19 (B19V), long known to be the causative agent of erythema infectiosum (fifth disease), is not a newly emerging agent. The aim of this review is to analyse the role played by this virus in compromising safety in transfusion medicine and the ...
Calizzani, Gabriele +7 more
core +1 more source
Considerations for the Use of AAV‐based Gene Therapy in HIV‐Positive Individuals With Haemophilia
ABSTRACT Introduction There is a high prevalence of human immunodeficiency virus (HIV) infection among the haemophilia community due to treatment in the 1970s and 1980s with contaminated clotting factor. Lifelong treatment regimens for haemophilia and HIV are burdensome alone and pose a particular challenge for individuals living with both conditions ...
Jürgen K. Rockstroh +5 more
wiley +1 more source
Francisella tularensis surveillance—infection-induced seroprevalences in Western Austria 2025
Background: Notified tularemia cases have been increasing in both the European Union and Austria, yet no contemporary seroprevalence data are available.
Anita Siller +11 more
doaj +1 more source
Empirical Bayes estimation of farm prevalence adjusting for multistage sampling and uncertainty in test performance: a Brucella cross-sectional serostudy in southern Kazakhstan [PDF]
Estimation of farm prevalence is common in veterinary research. Typically, not all animals within the farm are sampled, and imperfect tests are used.
Beauvais +8 more
core +2 more sources

