Results 151 to 160 of about 206,874 (310)

Synthetic Biology‐Based Engineering Living Therapeutics for Antimicrobial Application

Exploration, EarlyView.
This perspective highlights synthetic biology‐driven antibacterial strategies, focusing on three innovative approaches: engineered bacteriophages for precision bacterial targeting, reprogrammed microbes that detect quorum‐sensing signals or metabolites to release antimicrobials, and engineering mammalian cells that recognize pathogen‐associated ...
Shun Huang, Shuihao Zhao, Haijie Zhao, Mingzhang Wen, Zhong Guo   +4 more
wiley   +1 more source

Mobile Application for Dengue Fever Monitoring and Tracking via GPS: Case Study for Fiji [PDF]

arXiv, 2015
The 2013 outbreak of Dengue in Fiji resulted in an alarming number of deaths and has been is a matter of serious concern. Dengue fever is a disease caused by the four types of the Dengue virus serotypes and transmitted mostly from mosquito bites. In Fiji, dengue diagnosis is only done in hospitals which are slow and time consuming. It is also important
arxiv  

The complexity of serotype replacement of pneumococci [PDF]

Human Vaccines & Immunotherapeutics, 2019
Pneumococci respond extremely rapidly to the vaccine pressure created by the conjugate vaccines (PCVs). Vaccine serotypes are disappearing, meanwhile new, often previously very rare types are emerging, and it is difficult to establish what makes certain serotypes more successful in replacement.
openaire   +4 more sources

Pathogenic Escherichia coli Virulome in Top Soil Improvers and Irrigation Waters Devoted to Leafy Vegetable Production: Hazard Assessment From a Case Study in Italy

Food Safety and Health, EarlyView.
Escherichia coli pathotype virulotyping to assess if combined top soil improver and water inputs would potentially lead to hybrid strains with shuffled virulence features in ready‐to‐eat vegetables. This is to support the transition toward safe and sustainable food production systems.
Giorgia Barbieri, Federica Gigliucci, Sofia Palma, Fabio Minelli, Paola Chiani, Manuela Marra, Maria Carollo, Arnold Knijn, Gianfranco Brambilla, Stefano Morabito   +9 more
wiley   +1 more source

Clustering and Classification of Genetic Data Through U-Statistics [PDF]

arXiv, 2016
Genetic data are frequently categorical and have complex dependence structures that are not always well understood. For this reason, clustering and classification based on genetic data, while highly relevant, are challenging statistical problems. Here we consider a highly versatile U-statistics based approach built on dissimilarities between pairs of ...
arxiv  

Multi‐Omic Analysis Reveals Astrocytic Annexin‐A2 as Critical for Network‐Level Circadian Timekeeping in the Suprachiasmatic Nucleus

Glia, EarlyView.
ABSTRACT The mammalian suprachiasmatic nucleus (SCN) orchestrates daily (circadian) rhythms of physiology and behavior by broadcasting timing cues generated autonomously by its mutually reinforcing network of ~10,000 neurons and ~3000 astrocytes. Although astrocytic control of extracellular glutamate and GABA has been implicated in driving circadian ...
Andrew P. Patton, Toke P. Krogager, Elizabeth S. Maywood, Nicola J. Smyllie, Emma L. Morris, Mark Skehel, Michael H. Hastings   +6 more
wiley   +1 more source

FABP7 Expression Modulates the Response of Astrocytes to Induced Endotoxemia

Glia, EarlyView.
FABP7 silencing reduces inflammatory response in astrocytes. FABP7 silencing decreases astrocyte‐mediated neurotoxicity. FABP7 silencing attenuates NF‐κB‐dependent transcriptional response during endotoxemia. ABSTRACT Fatty acid binding proteins (FABPs) are a family of small proteins involved in fatty acid (FA) subcellular trafficking.
Mariana Bresque, Daniel Esteve, Garret Balmer, Haylee L. Hamilton, Joshua S. Stephany, Mariana Pehar, Marcelo R. Vargas   +6 more
wiley   +1 more source

Genotypic diversity and virulence factors of Streptococcus mutans in caries-free and caries-active individuals

Brazilian Archives of Biology and Technology, 2013
The objective of this study was to analyze the genotypic diversity, frequency of serotypes and the detection of mutacins from Streptococcus mutans isolates in caries-free and caries-active individuals.A total of 260 S. mutans isolated from 28 individuals
Miula Portelinha Braga, Augusta Piovesan, Natália Valarini, Sandra Mara Maciel, Flaviana Bombarda de Andrade, Regina Célia Poli-Frederico   +5 more
doaj  

Astroglial CB1 Reveal Sex‐Specific Synaptic Effects of Amphetamine

Glia, EarlyView.
Astroglial CB1R mediates long‐term synaptic plasticity (LTD) in the Nucleus accumbens. Amphetamine saturates adenosine receptors and blocks LTD in males, but not females. Locomotor effects of amphetamine require astroglial CB1R in males, but not in females.
Yamuna Mariani, Tommaso Dalla‐Tor, Tommaso Garavaldi, Francisca Julio‐Kalajzić, Doriane Gisquet, Paula Gomez‐Sotres, Astrid Cannich, Giuditta Gambino, Filippo Drago, Roman Serrat, Imane Hurel, Francis Chaouloff, Sandrine Pouvreau, Luigi Bellocchio, Giovanni Marsicano, Ana Covelo   +15 more
wiley   +1 more source

A Phase Diagram for Crystallization of a Complex Macromolecular Assembly [PDF]

arXiv
Crystallization of biological molecules has high potential to solve some challenges in drug manufacturing. Thus, understanding the process is critical to efficiently adapting crystallization to biopharmaceutical manufacturing. This article describes phase behavior for the solution crystallization of recombinant adeno-associated virus (rAAV) capsids of ...
arxiv