Results 151 to 160 of about 265,799 (334)

Optimal‐Control Techniques for Managing Dengue Outbreaks: An Advanced Mathematical Modeling

Natural Sciences, EarlyView.
ABSTRACT Dengue remains a major public health threat in tropical and subtropical regions. We develop a general human–vector SEIR–SEI optimal‐control framework that integrates four time‐dependent interventions: public awareness/behavioral protection, u1(t)${{u}_1}( t )$, enhanced clinical management u2(t)${{u}_2}( t )$, adulticide spraying u3(t)${{u}_3}(
Md. Sajib Miah, Md. Abdul Hye, Md. Shamim Hossain, Md. Mizanur Rahman   +3 more
wiley   +1 more source

Exposure to arboviral infections and risk of rheumatoid arthritis: Findings from the MyEIRA population‐based case‐control study

Rheumatology &Autoimmunity, EarlyView.
The Malaysian Epidemiological Investigation of Rheumatoid Arthritis population‐based case‐control study examined whether prior exposure to chikungunya and dengue viruses (via IgG seropositivity) is associated with rheumatoid arthritis (RA) risk, stratified by anti‐citrullinated protein antibody (ACPA) status.
Chun Lai Too, Wahinuddin Sulaiman, Nurul‐Aain Ahmad Fauzi, Siti Aisyah Abdul Ahmad, Lau Ing Soo, Heselynn Hussein, Nor‐Shuhaila Shahril, Gun Suk Chyn, Eashwary Mageswaran, Mohd‐Shahrir Mohamed Said, Lay Kim Tan, Ainon Mohd Mokhtar, Azmillah Rosman, Muhaini Othman, Osman Ali, Lars Alfredsson, Lars Klareskog, Leonid Padyukov   +17 more
wiley   +1 more source

Structural implications of BK polyomavirus sequence variations in the major viral capsid protein Vp1 and large T-antigen: a computational study

mSphere
BK polyomavirus (BKPyV) is a double-stranded DNA virus causing nephropathy, hemorrhagic cystitis, and urothelial cancer in transplant patients. The BKPyV-encoded capsid protein Vp1 and large T-antigen (LTag) are key targets of neutralizing antibodies and
Janani Durairaj, Océane M. Follonier, Karoline Leuzinger, Leila T. Alexander, Maud Wilhelm, Joana Pereira, Caroline A. Hillenbrand, Fabian H. Weissbach, Torsten Schwede, Hans H. Hirsch   +9 more
doaj   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Hybrid Vectors Based on Adeno-Associated Virus Serotypes 2 and 5 for Muscle-Directed Gene Transfer

, 2001
Markus Hildinger, Alberto Auricchio, Guangping Gao, Lili Wang, Narendra Chirmule, James M. Wilson   +5 more
openalex   +1 more source

Complete Genome Sequence of Colistin-Resistant Salmonella enterica Serotype Enteritidis Strain CRSE-01 Isolated from Poultry Carcass in South Korea

, 2023
Jun Bong Lee, Yewon Cheong, Se Kye Kim, Jang Won Yoon   +3 more
openalex   +2 more sources

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, EarlyView.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source

Serotype shift of a 793/B genotype infectious bronchitis coronavirus by natural recombination

, 2015
Tingting Zhang, Zongxi Han, Qianqian Xu, Qiuling Wang, Mengying Gao, Wei Wu, Yuhao Shao, Huixin Li, Xiangang Kong, Shengwang Liu   +9 more
openalex   +2 more sources

3D Quantification of Viral Transduction Efficiency in Living Human Retinal Organoids

Small Methods, EarlyView.
Optimization of viral vectors and their testing in human tissue is crucial to gene therapy development. Conventional technologies to assess virus transduction either lack spatial or temporal information. Here, spatiotemporal mapping of virus transduction in living retinal tissue is introduced, levering fluorescence imaging and machine learning‐based ...
Teresa S. Rogler, Katja A. Salbaum, Achim T. Brinkop, Selina M. Sonntag, Rebecca James, Elijah R. Shelton, Alina Thielen, Roland Rose, Sabrina Babutzka, Thomas Klopstock, Stylianos Michalakis, Friedhelm Serwane   +11 more
wiley   +1 more source

Treatment of Neurogenic Voice Disorders

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT This overview serves as a foundational resource for clinicians caring for neurologically complex patients presenting with voice complaints. Neurogenic voice disorders are diverse in their clinical presentations and therapeutic approaches. A thorough medical history, including family history, detailed laryngeal examination, voice assessments ...
Mausumi Syamal
wiley   +1 more source