Results 151 to 160 of about 219,974 (370)

New pyridobenothiazolone derivatives display nanomolar pan‐serotype anti‐DENV activity

ChemMedChem, Accepted Article.
Dengue virus (DENV) serotypes 1–4 are mosquito‐borne flaviviruses that are responsible for significant morbidity and mortality worldwide, particularly in tropical and subtropical regions. Although two vaccines have been approved, their unbalanced efficacy across serotypes poses potential risks for specific populations.
Tommaso Felicetti, Chin Piaw Gwee, Kitti Wing Ki Chan, Giacomo Pepe, Ciro Milite, Pietro Campiglia, Satoru Watanabe, Muhammad Danial Bin Mohd Mazlan, Stefano Sabatini, Serena Massari, Oriana Tabarrini, Gianluca Sbardella, Subhash G. Vasudevan, Giuseppe Manfroni   +13 more
wiley   +1 more source

Dynamics of Dengue with human and vector mobility [PDF]

arXiv, 2014
Dengue is a vector borne disease transmitted to humans by {\it{Aedes Aegypti}} mosquitoes carrying Dengue virus of different serotypes. Primarily an urban epidemic, Dengue exhibits complex spatial and temporal dynamics, influenced by many biological, human and environmental factors.
arxiv  

Population snapshot of emergent Streptococcus pneumoniae serotype 19A in the United States, 2005.

Journal of Infectious Diseases, 2008
BACKGROUND Serotype 19A invasive pneumococcal disease (IPD) increased annually in the United States after the introduction of the 7-valent conjugate vaccine (PCV7). To understand this increase, we characterized serotype 19A isolates recovered during 2005.
M. Moore, R. Gertz, Robyn L Woodbury, G. A. Barkocy-Gallagher, W. Schaffner, C. Lexau, K. Gershman, A. Reingold, M. Farley, L. Harrison, J. Hadler, N. Bennett, A. Thomas, L. McGee, T. Pilishvili, A. B. Brueggemann, C. Whitney, J. Jorgensen, B. Beall   +18 more
semanticscholar   +1 more source

Optimal Serotype Compositions for Pneumococcal Conjugate Vaccination under Serotype Replacement

PLoS Computational Biology, 2014
Pneumococcal conjugate vaccination has proved highly effective in eliminating vaccine-type pneumococcal carriage and disease. However, the potential adverse effects of serotype replacement remain a major concern when implementing routine childhood pneumococcal conjugate vaccination programmes.
Kari Auranen, Markku Nurhonen
openaire   +5 more sources

Genotypic diversity and virulence factors of Streptococcus mutans in caries-free and caries-active individuals

Brazilian Archives of Biology and Technology, 2013
The objective of this study was to analyze the genotypic diversity, frequency of serotypes and the detection of mutacins from Streptococcus mutans isolates in caries-free and caries-active individuals.A total of 260 S. mutans isolated from 28 individuals
Miula Portelinha Braga, Augusta Piovesan, Natália Valarini, Sandra Mara Maciel, Flaviana Bombarda de Andrade, Regina Célia Poli-Frederico   +5 more
doaj  

A Practical Approach to Implementing ICH Q14: Tools for Analytical Quality by Design in Capillary Electrophoresis Method Development

ELECTROPHORESIS, EarlyView.
ABSTRACT The ICH Q14 guideline introduces a structured framework for analytical method development based on Analytical Quality by Design (AQbD) principles, aiming to ensure robust, reliable, and fit‐for‐purpose methods throughout the product lifecycle.
Ewoud van Tricht, Cari E. Sänger ‐ van de Griend   +1 more
wiley   +1 more source

Identification and Differentiation of the Twenty Six Bluetongue Virus Serotypes by RT–PCR Amplification of the Serotype-Specific Genome Segment 2

PLoS ONE, 2012
Bluetongue (BT) is an arthropod-borne viral disease, which primarily affects ruminants in tropical and temperate regions of the world. Twenty six bluetongue virus (BTV) serotypes have been recognised worldwide, including nine from Europe and fifteen in ...
N. Maan, S. Maan, M. Belaganahalli, E. Ostlund, Donna J. Johnson, K. Nomikou, P. Mertens   +6 more
semanticscholar   +1 more source

Synthetic Biology‐Based Engineering Living Therapeutics for Antimicrobial Application

Exploration, EarlyView.
This perspective highlights synthetic biology‐driven antibacterial strategies, focusing on three innovative approaches: engineered bacteriophages for precision bacterial targeting, reprogrammed microbes that detect quorum‐sensing signals or metabolites to release antimicrobials, and engineering mammalian cells that recognize pathogen‐associated ...
Shun Huang, Shuihao Zhao, Haijie Zhao, Mingzhang Wen, Zhong Guo   +4 more
wiley   +1 more source

Determination of subtypes, serogroups, and serotypes, virulence, and/ or toxigenic properties of escherichia coli isolated from cattle, sheep, and goat feces by multiplex pcr [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi
In the study, rectal swabs taken from 300 ruminant animals including cattle (100), sheep (100), and goats (100) were inoculated into Mac Conkey Agar and incubated for 18 h at 37°C. Escherichia coli isolates were confirmed by biochemical tests and the BBL
Sibel KIZIL, Fatma Esin AYDIN, Aziz Utku ÖNEL, Murat YILDIRIM, Cansu ÖNLEN GÜNERİ, Efsun Melike ÇEÇEN   +5 more
doaj   +1 more source

Towards a Mathematical Foundation of Immunology and Amino Acid Chains [PDF]

arXiv, 2012
We attempt to set a mathematical foundation of immunology and amino acid chains. To measure the similarities of these chains, a kernel on strings is defined using only the sequence of the chains and a good amino acid substitution matrix (e.g. BLOSUM62). The kernel is used in learning machines to predict binding affinities of peptides to human leukocyte
arxiv