Results 211 to 220 of about 219,974 (370)

Correlation between staphylococcal serotypes with 263-1 factor and phage group 1 [PDF]

, 1966
Jay O. Cohen, Phillip D. Smith, Melinda Erwin, R M Fix   +3 more
openalex   +1 more source

Weakened Airway Epithelial Junctions and Enhanced Neutrophil Elastase Release Contribute to Age‐Dependent Bacteremia Risk Following Pneumococcal Pneumonia

Aging Cell, EarlyView.
During spread of Streptococcus pneumoniae from the lung to the bloodstream, the pneumococcal pore‐forming toxin pneumolysin (PLY) disrupts apical junction complexes (AJCs) and triggers the transmigration of polymorphonuclear leukocytes (PMNs), which secrete tissue‐destructive neutrophil elastase.
Shuying Xu, Tianmou Zhu, Hongmei Mou, Shumin Tan, John M. Leong   +4 more
wiley   +1 more source

Astrocytic Hevin/SPARCL‐1 Regulates Cognitive Decline in Pathological and Normal Brain Aging

Aging Cell, EarlyView.
Hevin/Sparcl‐1 is a synaptogenic protein secreted by astrocytes. We used adeno‐associated virus (AAV) to increase its expression in hippocampal astrocytes of APP/PSEN1 mice, an animal model for Alzheimer's disease (AD). This procedure improved cognitive performance both in the AD model and in middle‐aged wild‐type animals.
Felipe Cabral‐Miranda, Ana Paula Bergamo Araujo, Danilo Bilches Medinas, Flávia Carvalho Alcantara Gomes   +3 more
wiley   +1 more source

Reduction of DNA Topoisomerase Top2 Reprograms the Epigenetic Landscape and Extends Health and Life Span Across Species

Aging Cell, EarlyView.
This study demonstrates that reducing the enzyme topoisomerase Top2 or its mammalian homolog TOP2B promotes longevity across multiple species, including yeast, worms, and mice. At the cellular/molecular level, TOP2B reduction mitigates the major cellular aging hallmarks such as epigenetic alterations, cell senescence, lysosomal biogenesis, and ...
Man Zhu, Meng Ma, Lunan Luo, Feiyang Li, Jiashun Zheng, Yan Pan, Lu Yang, Ying Xiao, Ziyan Wang, Bo Xian, Yi Zheng, Hao Li, Jing Yang   +12 more
wiley   +1 more source

Identification of All Dengue Serotypes in Nepal

Emerging Infectious Diseases, 2008
Sarala Malla, Garib D. Thakur, Sanjaya K. Shrestha, Manas K. Banjeree, Laxmi B. Thapa, Gyanendra Gongal, Prakash Ghimire, Bishnu P. Upadhyay, Purosotam Gautam, Shyam Khanal, Ananda Nisaluk, Richard G. Jarman, Robert V. Gibbons   +12 more
doaj   +1 more source

Immune Response of Cattle to Different Serotype Antigens in Monovalent and Trivalent Foot-and-Mouth Disease Vaccines [PDF]

, 1969
J. H. Graves
openalex   +1 more source

Senescent Macrophages Promote Age‐Related Revascularization Impairment by Increasing Antiangiogenic VEGF‐A165B Expression

Aging Cell, EarlyView.
The underlying mechanisms of age‐related revascularization impairment are not clear. Our research firstly identified that macrophages were more senescent in the ischemic skeletal muscle of old mice and senescent macrophages could inhibit revascularization.
Minghong Chen, Junyu Chen, Yu Liu, Xuerui Wang, Meilian Yao, Jing Chen, Jian Zhang, Qun Huang   +7 more
wiley   +1 more source

Selective Enrichment of Full AAV Capsids [PDF]

arXiv
Gene therapies using recombinant adeno-associated virus (rAAV) have been developed to treat monogenic and acquired diseases but are currently the most expensive drugs due, in part, to high manufacturing costs. The cells producing rAAV generate substantial quantities of empty (50-90%) and partially filled capsids that must be removed prior to final ...
arxiv  

An undescribed Salmonella serotype: S. cairns

, 1967
Katherine Anderson, Helen McDonald
openalex   +1 more source

SALMONELLA ELSIESRIVIER , A NEW SEROTYPE (16:Z ₄₂ :1,6) [PDF]

, 1962
H. D. Brede
openalex   +1 more source