Results 261 to 270 of about 268,563 (331)

Public health effects of adult pneumococcal vaccination choice amid increased serotype 4 rates in US subpopulations. [PDF]

Public Health
Smith KJ, Wateska AR, Nowalk MP, Lin CJ, Harrison LH, Schaffner W, Altawalbeh SM, Zimmerman RK.   +7 more
europepmc   +1 more source

Microglial Deletion of Hrh4 Alleviates Alzheimer's Disease Pathologies by Enhancing Microglial Phagocytosis of Amyloid‐β and Tau

Advanced Science, Volume 13, Issue 2, 9 January 2026.
Histamine H4 receptor (H4R) antagonist VUF6002 mimics low‐dose X‐ray irradiation in aged Alzheimer's disease (AD) mice, enhancing microglial clearance of amyloid‐beta/hyperphosphorylated tau aggregates and restoring cognition. Microglial H4R deletion activates cAMP/TGF‐β1/Smad3 pathway, enhancing phagocytosis, while TGF‐β receptor 1 deletion abolishes ...
Yi‐Jun Xu, Tan Wu, Larry Tso‐Lun Lo, Chi‐Chiu Ko, Xin Wang, Chi Him Eddie Ma   +5 more
wiley   +1 more source

Serotype diversity and risk factors for pneumococcal carriage among healthy children in Klang Valley, Malaysia: A pre-vaccination cross-sectional study. [PDF]

IJID Reg
Arushothy R, Tan CN, Nor Amdan NA, Mohd Ali MR, Mohd Tap R, Paliappan PA, Liow YL, Maniam S, Mohamed Sukur S, Hashim R.   +9 more
europepmc   +1 more source

Lipopolysaccharide Serotyping of Vibrio Vulnificus.

, 1989
Stephen R. Martin, Stephen Martin
openalex   +2 more sources

Activation of USP30 Disrupts Endothelial Cell Function and Aggravates Acute Lung Injury Through Regulating the S‐Adenosylmethionine Cycle

Advanced Science, Volume 13, Issue 2, 9 January 2026.
USP30 deubiquitinates and stabilizes MAT2A, thereby regulating DNA methylation and miRNA expression, which ultimately leads to disruption of lung endothelial barrier and inflammation. Abstract Microvascular dysfunction is a key contributor to the development of acute inflammatory diseases, characterized by heightened vascular hyperpermeability and ...
Baoyinna Baoyinna, Jinshan He, Jiaxing Miao, Nargis Shaheen, Boyu Xia, Cankun Wang, Qin Ma, Matthew C Bernier, Bryan A Whitson, Nuo Sun, Jing Zhao, Yutong Zhao   +11 more
wiley   +1 more source

Fluorescent Nanodiamonds for Lateral Flow Assays Enhanced by Magnetic Modulation: From Synthesis to Application

Advanced Energy and Sustainability Research, Volume 7, Issue 1, January 2026.
This review examines the use of fluorescent nanodiamonds (FNDs) in lateral flow assays (LFAs) for advanced diagnostics. FNDs offer superior photostability and biocompatibility compared to traditional labels. The review covers FND synthesis, and integration with detection systems to enhance performance.
Jihoon Shin, Sihyeok Kim, Chan‐Woo Jung, Seojin Koh, Esko I. Kauppinen, Mina Lee, Seung‐Jin Yoo, Hak‐Sung Jung, Jeong Hyun Shim, Dong‐Hwan Kim, Il Jeon   +10 more
wiley   +1 more source

Engineering of High‐Yield Recombinant Adeno‐Associated Virus Producer Plasmids

Biotechnology Journal, Volume 21, Issue 1, January 2026.
Graphical Abstract and Lay Summary Recombinant adeno‐associated viruses (AAV) are important in gene therapy but their production may be impaired by non‐optimized gene design. In this study, the authors demonstrate that production was best when the AAV replicase gene was in a wild‐type configuration while the complexity of other genetic elements could ...
Marco T. Radukic, Dinh To Le, Robert Freudenberg, Anne Hammann, Omar Hamdan, Claire Rothschild‐Gronau, Raimund Hoffrogge, Susanne K. Golm, Rebecca C. Feiner, Kathrin E. Teschner, Kristian M. Müller   +10 more
wiley   +1 more source

Downstream Process Intensification for AAV Purification by Affinity Chromatography Using Single Pass Tangential Flow Filtration

Biotechnology and Bioengineering, Volume 123, Issue 1, Page 174-185, January 2026.
ABSTRACT To enable adeno‐associated viral vectors (AAV) to achieve their maximum potential, next‐generation manufacturing processes must be developed to make gene therapies more affordable and accessible. This study focused on the design of two different intensified AAV downstream manufacturing processes at bench and pilot scale.
Akshay S. Chaubal, Ronny Horax, Christopher J. Yehl, S. Ranil Wickramasinghe, Xianghong Qian, Lu Wang, Andrew L. Zydney   +6 more
wiley   +1 more source

Could the Biological Potency of Porcelia macrocarpa R.E. Fries (Annonaceae) be Linked to Its Diverse Metabolite Profile?

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT Porcelia macrocarpa is a Brazilian plant species belonging to the Annonaceae family. To date, more than 190 compounds have been identified and/or isolated from this species, with terpenoids comprising the majority (62%). Alkaloids represent the second most abundant class (11%), followed by steroids (4%), acetogenins (4%), fatty acids (4 ...
Fernanda Thevenard, Ivanildo A. Brito, Emerson A. Oliveira, Mariana H. Chaves, João Henrique G. Lago   +4 more
wiley   +1 more source

Expansion of the Group B <i>Streptococcus</i> serotype repertoire via gene acquisition from other streptococcal species. [PDF]

Microbiol Spectr
Sharp ME, Sproch J, Haldeman S, Tettelin H, Ratner AJ.   +4 more
europepmc   +1 more source