Results 51 to 60 of about 307,730 (226)

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

Proportion and risk factors of retinal changes in pregnant women with HELLP syndrome

BMC Pregnancy and Childbirth
Background/aims To report the proportion and risk factors associated with retinal changes in Chinese pregnant women diagnosed with HELLP syndrome. Methods A retrospective review of medical records was conducted for all pregnant women with HELLP syndrome ...
Lasi Wu, Wenyao Chen, Mai Ye, Tong Zhou, Da Lin, Haihua Zheng, Lianyun Wang, Haishuang Lin   +7 more
doaj   +1 more source

KIF1A‐Mediated Axonal Transport of Netrin‐1 in iPSC‐Derived Human Forebrain Neurons

Cytoskeleton, EarlyView.
ABSTRACT Netrin‐1 is a secreted laminin‐like protein that functions as a guidance cue for axon pathfinding in development. Netrin‐1 also modulates synapse formation in developing neurons and long‐term potentiation in mature neurons. Netrin‐1 is expressed in human neurons; however, its intracellular distribution and trafficking have not been assessed ...
T. Y. Leung, J. Sidhu, A. Hsieh, Y. Ma, J. Liu, M. A. Silverman   +5 more
wiley   +1 more source

Fhod3 in zebrafish supports myofibril stability during growth of embryonic skeletal muscle

Developmental Dynamics, EarlyView.
Abstract Background Actin filament organization in cardiomyocytes critically depends on the formin Fhod3, but a role for Fhod3 in skeletal muscle development has not yet been described. Results We demonstrate here that in zebrafish mutated for one of two fhod3 paralog genes, fhod3a, skeletal muscle of the trunk appears normal through 2 days post ...
Aubrie Russell, Tracy Eng, Jeffrey D. Amack, David Pruyne   +3 more
wiley   +1 more source

Transient Serous Retinal Detachment Possibly Related to Strenuous Exercise

, 2017
Purpose: To report a case of transient serous retinal detachment, which may have been caused by hypertensive choroidopathy associated with exercise.
Anna Ells, Michael Fielden, Matthew Frederick Anderson   +2 more
core   +1 more source

Bilateral serous retinal detachment associated with end-stage renal disease

Indian Journal of Ophthalmology. Case Reports
We present a 27-year-old female with chronic renal disease and history of congenital renal hypoplasia currently under peritoneal dialysis. She was referred for sudden vision loss.
Danna A Alvirde-Ayala, Martin Marie-Tognola, Erick A Quiroz-Gonzalez, Jaime A Mendoza-Chavez   +3 more
doaj   +1 more source

Prepapillary Vascular Loops Complicated by Suspected Macroaneurysm Rupture

Case Reports in Ophthalmological Medicine, 2014
We present a case of prepapillary vascular loops complicated by a suspected macroaneurysm rupture which was treated with intravitreal bevacizumab (IVB). A 62-year-old woman presented with decreased vision and myodesopsia in her left eye.
Kei Akaiwa, Yoshinori Mitamura, Takashi Katome, Kentaro Semba, Mariko Egawa, Takeshi Naito   +5 more
doaj   +1 more source

Association between periodontitis and exudative retinal detachment: A population‐based cohort study

Journal of Periodontology, EarlyView.
Abstract Background To investigate whether periodontitis, a common bacterial‐induced inflammatory condition, serves as a risk factor for exudative retinal detachment (ERD), which results from fluid entering the subretinal space due to damage to the retinal pigment epithelium or leaky intraocular vessels, typically associated with inflammatory ...
Earl Fu, Ming‐Ling Tsai, Tsu‐Hsuan Weng, Chi‐Hsiang Chung, Min‐Wen Fu, Wu‐Chien Chien   +5 more
wiley   +1 more source

Bilateral serous retinal detachments associated with burkitt lymphoma

American Journal of Ophthalmology Case Reports, 2020
To report a case of bilateral serous retinal detachments in a patient found to have burkitt lymphoma.A patient who presented with bilateral serous retinal detachments and "B" symptoms underwent extensive workup and was found to have burkitt lymphoma.
Matthew S. Wieder, Jay A. Fleischman, Saadia Rashid   +2 more
openaire   +3 more sources

Movement of intraretinal fluid from distant branch retinal vein occlusion to the submacular space

Clinical Ophthalmology, 2013
Tomohiro Otani, Yumiko Yamaguchi, Shoji KishiDepartment of Ophthalmology, Gunma University School of Medicine, Maebashi, Gunma, JapanBackground: Extramacular branch retinal vein occlusion (BRVO) occasionally causes serous macular detachment.
Otani T, Yamaguchi Y, Kishi S
doaj