Results 151 to 160 of about 3,295,861 (246)

Single‐Nucleus Atlas of Spinal Sarcopenia Patients Reveals Disruption of Quiescent and Regenerative Satellite Cell Niches in Fatty‐Infiltrated Muscle

Advanced Science, EarlyView.
Mechanisms of Fatty Infiltration and Muscle Degeneration. Clinical metadata identified intramuscular fat accumulation as an independent driver of muscle mass decline. Single‐nucleus RNA sequencing of spinal sarcopenia muscle revealed adipogenic reprogramming of fibro‐adipogenic progenitors, satellite‐cell niche disruption, and elevated levels of the ...
Wenkai Wu, Renxian Wang, Dingding Wang, Quanzhong Ren, Ling Wang, Fangfang Duan, Guihe Yang, Ruixuan Yu, Yi Wang, Yingyu Zhang, Zetong Zang, Chuqi Li, Weijia Liu, Wenshuang Zhang, Yi Yuan, Zitong Cheng, Xiaoguang Cheng, Junbo Liang, Yajun Liu   +18 more
wiley   +1 more source

Bio-Inspired Blade Serrations: A Review on Owl-Based Strategies for Aeroacoustic Noise Mitigation. [PDF]

Biomimetics (Basel)
Nieto A, Marin-Calvo N.
europepmc   +1 more source

Effect of Mn addition on serrated plastic flow behaviour in high-strength multiphase steels with retained austenite

, 2019
PING 2019 is organized with the support of funds for specific university research project SVK1-2019-002.The effect of manganese addition (from 3 to 5%) on the serrated plastic flow behavior in medium manganese TRIP steels was investigated in static ...
Grzegorczyk, Barbara, Staszuk, Marcin, Kozłowska, Aleksandra, Grajcar, Adam   +3 more
core  

Expanding Genetic Code to Generate Human Brain Organoids with Both Vasculature and Microglia‐Like Cells

Advanced Science, EarlyView.
Using genetic code expansion, we engineered vascularized human cerebral organoids (vhCOs) with microglia‐like cells and blood‐brain barrier features. vhCOs recapitulate neurovascular interactions, regional identities, and neuronal subtypes resembling the fetal brain.
Haishuang Lin, Yaqing Wang, Hu Du, Yuxin Qin, Haoyu Zhang, Peng Wang, Lin Wei, Jianhua Qin   +7 more
wiley   +1 more source

Integrative microbiome-methylome analysis links bacterial taxa to colorectal cancer histological subtypes. [PDF]

mSystems
Escudero-Jiménez Á, Galán-Ros J, Huertas-López F, Pérez-Sarabia A, Ribeiro D, Postigo-Corrales F, Albaladejo-González A, Díaz-López MI, López-Abellán MD, García-Rodríguez J, Beltrán-Videla MA, Arroyo AB, Hurtado López AM, Tapia-Abellán A, Corral San Miguel R, Rodríguez-Braun E, Feliciangeli E, Sánchez-Espinosa A, Conesa A, Luengo-Gil G, Conesa-Zamora P.   +20 more
europepmc   +1 more source

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source

A 3D‐Printed SFE‐Graded Alloy Mitigates Cryogenic Discontinuous Plastic Flow and Hydrogen Embrittlement

Advanced Science, EarlyView.
A novel strategy features gradient composition and stacking fault energy‐tuned (CoCrMn)100‐2xFexNix fabricated via in situ alloying additive manufacturing. This design circumvents cryogenic discontinuous plastic flow and hydrogen embrittlement of metallic materials under quasi‐static loading and hydrogen‐rich environment relevant to lunar polar ...
Renhao Wu, Ao Geng, Peihao Geng, Hyojin Park, Eun Seong Kim, Sang‐Ho Oh, Stephan Schönecker, Xiaoqing Li, Tianlong Zhang, Shuhui Li, Byeong‐Joo Lee, Hyoung Seop Kim   +11 more
wiley   +1 more source

Sessile serrated lesions of the appendix: a contemporary review of the literature. [PDF]

BMC Gastroenterol
Csonka B, Lantos T, Sejben A.
europepmc   +1 more source

scGEN: Leveraging an Adaptive Weighting Strategy for Challenging Cell Clustering in Single‐Cell RNA‐seq

Advanced Science, EarlyView.
scGEN combines attribute–structure encoding, adaptive hard‐sample weighting, and regularized zero‐inflated negative binomial loss to resolve ambiguous single‐cell states. In the developing human pituitary, refined annotations reveal Pre.Gonado cells at 7 weeks and previously obscured developmental communication networks.
Fang Huang, Dayu Hu, Yaqi Dai, Aoyi Geng, Renxiang Guan, Hao Quan, Brett A. McGregor, Zhihan Wang, Nadeem Khan, Hongsheng Zhang, Jinghua Zhang, Mingyang Xia, Xiaoqiong Gu, Di Che, Junguk Hur, Xiaoyu Cui, Kai Guo   +16 more
wiley   +1 more source

The Decoupling of Hardness and Elastic Modulus in Ti-Based Metallic Glasses Induced by Elastic Pretreatment. [PDF]

Materials (Basel)
Wang A, Wang Y, Hou L, Sun H, Xie X, Duan J, Li C, Li Y.   +7 more
europepmc   +1 more source