Results 211 to 220 of about 33,675 (255)

MurNAc‐Based Electrophilic Inhibitors of O‐Acetylpeptidoglycan Esterase (Ape): Design, Synthesis, and Kinetic Evaluation

open access: yesChemistry – A European Journal, EarlyView.
A series of N‐acetylmuramic acid (MurNAc)‐based electrophilic inhibitors targeting Ape esterase was synthesized. Their inhibitory potency ranged from micromolar to submillimolar. The study probed binding contributions of stem peptide extension, replacing the anomeric methyl group with a benzyl, and α‐fluorination of the carbonyl to enhance ...
Dmytro Voskoboinyk, Martin E. Tanner
wiley   +1 more source

Chiral Gold Nanofibers as Substrates Toward SERS‐Based Chiral and Flexible Sensing

open access: yesChemistry – A European Journal, EarlyView.
High‐aspect‐ratio chiral gold nanofibers are a recently reported low‐dimensional material with intrinsic chiroptical properties. Here, we use them as label‐free SERS substrates for the identification of enantiomers in mixtures and detection of model compounds on the surface of paper chip‐based platforms.
Mathias R. S. Nielsen   +4 more
wiley   +1 more source

Copula‐based joint modelling of emergency department visits with time‐varying dependence

open access: yesCanadian Journal of Statistics, EarlyView.
Abstract Jointly modelling multiple correlated count time series is essential in health services research, where outcomes like emergency visits for mental health and substance use often evolve together. Ignoring these dependencies can obscure meaningful trends and limit the effectiveness of policy evaluation.
Guanjie Lyu, Cindy Feng, Lihui Liu
wiley   +1 more source

Extreme conditional quantile estimation for time series

open access: yesCanadian Journal of Statistics, EarlyView.
Abstract We consider the estimation of an extreme conditional quantile QY(1−p|x0)$$ {Q}_Y\left(1-p|{x}_0\right) $$ for a heavy‐tailed distribution in the case of a strictly stationary time series (Xt,Yt)t∈ℤ$$ {\left({X}_t,{Y}_t\right)}_{t\in \mathbb{Z}} $$. Here, QY(·|x0)$$ {Q}_Y\left(\cdotp |{x}_0\right) $$ denotes the conditional quantile function of
Yuri Goegebeur   +2 more
wiley   +1 more source

Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Solute carriers (SLC) and ATP‐binding cassette (ABC) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear.
Elijah Marsh Jung   +12 more
wiley   +1 more source

Detection of Lower Molecular Mass Peptides, Steroid Esters, and Multi‐Class Substances in a Single Dried Blood Spot for Comprehensive Initial Testing in Doping Control

open access: yesDrug Testing and Analysis, EarlyView.
A validated LC‐HRMS/MS method enabled, for the first time, the simultaneous detection of lower molecular mass peptides, steroid esters, and multi‐class menu substances from a single dried blood spot, maximizing analytical coverage while minimizing sample consumption through post‐extraction splitting into two aliquots.
Panagiotis Sakellariou   +3 more
wiley   +1 more source

Towards Reliable and Quantitative Surface-Enhanced Raman Scattering (SERS): From Key Parameters to Good Analytical Practice [PDF]

open access: yesAngewandte Chemie - International Edition, 2020
Experimental results obtained in different laboratories world‐wide by researchers using surface‐enhanced Raman scattering (SERS) can differ significantly.
Emiliano Cortés   +2 more
exaly   +2 more sources
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Ser or not ser: That Is the Question

Hispania, 1985
Some recent research in foreign-language education has suggested that many of the activities teachers traditionally engage in are either useless, or worse, counterproductive. From Krashen 1981' and 1982 and from sources cited therein one might easily conclude that foreign-language teachers should not teach anything.
openaire   +1 more source

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