Results 291 to 300 of about 1,288,749 (348)

Interpretable PROTAC Degradation Prediction With Structure‐Informed Deep Ternary Attention Framework

Advanced Science, EarlyView.
PROTAC‐STAN, a structure‐informed deep learning framework is presented for interpretable PROTAC degradation prediction. By modeling molecular hierarchies and protein structures, and simulating ternary interactions via a novel attention network, PROTAC‐STAN achieves significant performance gains over baselines.
Zhenglu Chen, Chunbin Gu, Shuoyan Tan, Xiaorui Wang, Yuquan Li, Mutian He, Ruiqiang Lu, Shijia Sun, Chang‐Yu Hsieh, Xiaojun Yao, Huanxiang Liu, Pheng‐Ann Heng   +11 more
wiley   +1 more source

Transfer-Free Conformal Graphene Coating on Pyramidal Microstructures Decorated with Silver Nanoparticles for Superior Raman Signal Enhancement. [PDF]

ACS Appl Mater Interfaces
Lai CY, Lin YX, Lin EJ, Lin CC, Chen CC.
europepmc   +1 more source

The CtrCBL1/CtrCIPK6 Complex of Citrus Phosphorylates CtrBBX32 to Regulate CtrSTP1‐Mediated Sugar Accumulation and Cold Tolerance

Advanced Science, EarlyView.
The CtrCBL1‐CtrCIPK6 module of trifoliate orange (Citrus trifoliata L.) phosphorylates CtrBBX32, triggering its protein degradation under cold conditions, thereby relieving CtrBBX32‐mediated transcriptional repression of CtrZAT10 and CtrSTP1. The consequent upregulation of CtrZAT10 further activates CtrSTP1 expression, which enhances hexose transport ...
Xiangming Shang, Zeqi Zhao, Wei Xiao, Yike Zeng, Mengdi Li, Xin Jiang, Bachar Dahro, Lele Chu, Min Wang, Chunlong Li, Ji‐Hong Liu   +10 more
wiley   +1 more source

Current Density Optimization for SERS Substrates Using Galvanostatically Anodized TiO₂ Nanostructures Decorated with Pulsed-Electrodeposited Silver Dendrites. [PDF]

Materials (Basel)
Luna-Cervantes M, García-Ramírez JI, Hernández-Torres J, Zamora-Peredo L.   +3 more
europepmc   +1 more source

“PRA SER HOMEM TEM QUE TER PÊNIS”: INTERDIÇÕES A POPO VAZ E THAMMY MIRANDA

Bruno Henrique Machado Oliveira, Luana Alves Luterman, Guilherme Figueira-Borges   +2 more
openalex   +1 more source

Stage‐Resolved Phosphoproteomic Landscape of Mouse Spermiogenesis Reveals Key Kinase Signaling in Sperm Morphogenesis

Advanced Science, EarlyView.
The quantitative proteomic and phosphoproteomic profiling reveals dynamic phosphorylation regulation of sperm morphogenesis. Kinase‐substrate phosphorylation network and phosphorylation module analysis, followed by in vivo knockdown and knockout analysis, identify TTBK2 and CSNK1G1 as key regulators of morphogenesis, including head, flagellar, and ...
Tianyu Zhu, Yan Zhu, Xinyi Jiang, Xiangzheng Zhang, Bing Wang, Yu Chen, Yichen Zhao, Yulian Wang, Qi Zhou, Zhongyan Han, Yaling Qi, Mengjiao Luo, Haixia Tu, Bingjie Hao, Mengmeng Gao, Jie Ren, Xin Zhou, Xingyu Zhang, Xu Chen, Haojie Li, Qian Huang, Chenghao Situ, Yueshuai Guo, Hui Zhu, Yan Li, Xuejiang Guo   +25 more
wiley   +1 more source

Semiconducting Tungsten Trioxide Thin Films for High-Performance SERS Biosensors. [PDF]

Nanomaterials (Basel)
Liu H, Chen L, Li B, Song H, Tan CL, Shi Y, Yan S.   +6 more
europepmc   +1 more source

cGAS Inhibits ALDH2 to Suppress Lipid Droplet Function and Regulate MASLD Progression

Advanced Science, EarlyView.
cGAS is a cytosolic DNA sensor known for innate immune defense. cGAS binds and suppresses ALDH2 are showed, limiting acetyl‐CoA production. cGAS loss activates ALDH2, promoting histone acetylation, lipogenesis, and lipid droplets accumulation. cGas‐/‐ mice on a high‐fat diet show signs of worsened MASLD.
Ying Wang, Yu Deng, Jianfeng Chen, Quentin Hahn, David S. Umbaugh, Zhigang Zhang, Yanqiong Zhang, Sarah E. Rowe, Lupeng Li, Laura E. Herring, Brian P. Conlon, Edward A. Miao, Blossom Damania, Anna Mae Diehl, Pengda Liu   +14 more
wiley   +1 more source

Green synthesis of Ag@Cu and silver nanowire using Pterospermum heterophyllum extracts for surface-enhanced Raman scattering

Green Processing and Synthesis
Cao Khoa Tien, Do Hue Thi
doaj   +1 more source

A Highly Sensitive SERS Technique Based on Au NPs Monolayer Film Combined with Multivariate Statistical Algorithms for Auxiliary Screening of Postmenopausal Osteoporosis. [PDF]

Biosensors (Basel)
Yu Y, Hu J, Shen Q, Xu H, Wang S, Wang X, Zhong Y, He T, Huang H, Hong Q, Huang E, Li X.   +11 more
europepmc   +1 more source