Results 61 to 70 of about 5,326,178 (309)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Interleukin-10 containing normal human serum inhibits granzyme B release but not perforin release from alloreactive and EBV-specific T cell clones [PDF]

, 2007
Interleukin-10 (IL-10), also known as cytokine synthesis inhibitory factor, has pleiotropic effects in immunoregulation and inflammation. It is capable of inhibiting synthesis of pro-inflammatory cytokines like interferon γ (IFNγ), IL-2, IL-3,
Hideya Sato, Hitoshi Okazaki, Kenji Tadokoro, Masahiro Satake, Motoko Nishimura   +4 more
core   +2 more sources

Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer's disease [PDF]

, 2019
Neurofilament light chain (NfL) is a promising fluid biomarker of disease progression for various cerebral proteopathies. Here we leverage the unique characteristics of the Dominantly Inherited Alzheimer Network and ultrasensitive immunoassay technology ...
Allegri, Ricardo, Alzheimer Network, Amtashar, Fatima, Apel, Anja, Barro, Christian, Bateman, Randall, Bateman, Randall J., Benzinger, Tammie, Benzinger, Tammie L. S., Berman, Sarah, Bodge, Courtney, Brandon, Susan, Brooks, William, Buck, Jill, Buckles, Virginia, Chea, Sochenda, Chhatwal, Jasmeer, Chhatwal, Jasmeer, Chrem, Patricio, Chui, Helena, Cinco, Jake, Clifford, Jack, Cruchaga, Carlos, DiBari, Siri Houeland, Donahue, Tamara, Douglas, Jane, D’Mello, Mirelle, Edigo, Noelia, Erekin-Taner, Nilufer, Fagan, Anne, Fagan, Anne M., Farlow, Marty, Farrar, Angela, Feldman, Howard, Flynn, Gigi, Fox, Nick, Franklin, Erin, Fujii, Hisako, Gant, Cortaiga, Gardener, Samantha, Ghetti, Bernardino, Ghetti, Bernardino, Goate, Alison, Goate, Alison M., Goldman, Jill, Gordon, Brian, Gordon, Brian A., Graff-Radford, Neill, Graff-Radford, Neill R., Gray, Julia, Gräber, Susanne, Gurney, Jenny, Hassenstab, Jason, Hirohara, Mie, Holtzman, David, Hornbeck, Russ, Ikeuchi, Takeshi, Ikonomovic, Snezana, Jerome, Gina, Jucker, Mathias, Jucker, Mathias, Kaeser, Stephan A., Karch, Celeste, Kasuga, Kensaku, Kawarabayashi, Takeshi, Klunk, William, Koeppe, Robert, Kuder-Buletta, Elke, Kuder-Buletta, Elke, Kuhle, Jens, LaFougere, Christian, Laske, Christoph, Laske, Christoph, Lee, Jae-Hong, Levin, Johannes, Levin, Johannes, Marcus, Daniel, Martins, Ralph, Martins, Ralph, Mason, Neal Scott, Masters, Colin, Masters, Colin L., Maue-Dreyfus, Denise, McDade, Eric, McDade, Eric M., Montoya, Lucy, Mori, Hiroshi, Morris, John, Morris, John C., Nagamatsu, Akem, Neimeyer, Katie, Noble, James, Noble, James M., Norton, Joanne, Perrin, Richard, Preische, Oliver, Raichle, Marc, Ringman, John, Ringman, John M., Roh, Jee Hoon, Rossor, Martin N., Salloway, Stephen, Salloway, Stephen, Schofield, Peter, Schofield, Peter R., Schultz, Stephanie A., Shimada, Hiroyuki, Shiroto, Tomoyo, Shoji, Mikio, Sigurdson, Wendy, Sohrabi, Hamid, Sparks, Paige, Suzuki, Kazushi, Swisher, Laura, Taddei, Kevin, Vöglein, Jonathan, Wang, Guoqiao, Wang, Jen, Wang, Peter, Weiner, Mike, Wolfsberger, Mary, Xiong, Chengjie, Xu, Xiong   +122 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

A Clinically Relevant Cationic Adjuvant System Induces Th17 T Cells Involved in Skin and Upper Airway Infections with Streptococcus pyogenes

Proceedings
Streptococcus pyogenes (Group A Streptococcus, StrepA) is a human pathogen responsible for hundreds of millions of infections each year and remains one of the most prevalent bacterial causes of upper respiratory and skin infections worldwide [...]
Kristoffer Mazanti Melchiors, Nina Dieu Nhien Tran Nguyen, Sharmila Subratheepam, Ida Rosenkrands, Frank Follmann, Jes Dietrich   +5 more
doaj   +1 more source

Immunogenicity and Therapeutic Efficacy of a Sendai-Virus-Vectored HSV-2 Vaccine in Mouse and Guinea Pig Models

Vaccines, 2023
Background: To date, there is no licensed vaccine for preventing herpes simplex virus type 2 (HSV-2). The current treatment to address the infection and prevent its transmission is not always satisfactory. Methods: We constructed two recombinant vectors,
Xiuxiu Ren, Wenhao Su, Shishi Li, Tingting Zhao, Qiufang Huang, Yinan Wang, Xiaojie Wang, Xiaohuan Zhang, Jiangbo Wei   +8 more
doaj   +1 more source

Effect of Oocyte Vitrification Before and After in Vitro Maturation Towards Bcl-2, Bax and Bcl-2/Bax Ratio Expression [PDF]

, 2016
Objectives: to compare the expression of Bcl-2, Bax and Bcl-2/Bax ratio in cumulus cell and oocyte between vitrified oocyte pre and post in vitro maturation.Materials and Methods: Maturation was operated in medium TC 100 µl for 24 hours.
Aswin, H. (Haryanto), Faizah, Z. (Zakiyatul), Lunardhi, H. (Hamdani)   +2 more
core  

The influence of protein adsorption on interactions of cultured human endothelial cells with polymers [PDF]

, 1987
A systematic study of the effects of polymer surface properties on the interaction with human endothelial cells (HEC) may lead to the development of small-diameter vascular grafts.
Aken, W.G. van, Bantjes, A., Beugeling, T., Detmers, J.P., Feijen, J., Vreriks, C.M., Wachem, P.B. van   +6 more
core   +4 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Tumores desmoides: cuadro clínico y sobrevida

Revista Médica Herediana, 1998
Objetivos: Identificar el cuadro clínico, la recurrencia y sobrevida quinquenal por tumor desmoide. Material y métodos: Analizamos 18 pacientes manejados en el Hospital Belén, Trujillo, Perú, desde 1966 a 1994. Resultados: Los antecedentes más frecuentes
Juan Díaz-Plasencia, Alejandro Cruz Lezcano, Luz Cisneros Infantas, Jorge Pomamanta Plasencia, Guillermo Fonseca Risco   +4 more
doaj