Results 121 to 130 of about 1,546,756 (303)

Distribution and Alkaline phosphatatase activity of filamentous conjugales in an upper Teesdale stream [PDF]

, 1992
Two small streams in Upper Teesdale National Nature Reserve were examined with respect to water chemistry and filamentous Conjugales present. Phosphate, nitrate and ammonia concentrations in the water were determined, to investigate a possible link ...
Casey, Catherine
core  

Engineered Allosteric Biosensor for In Situ DNA Glycosylase Detection in Neuroblastoma Risk Stratification and Drug Resistance Monitoring

Advanced Science, EarlyView.
An engineered allosteric biosensor (UUU‐DZ‐tFNA) was developed, in which UDG specifically recognizes and activates a DNAzyme to achieve signal cycle amplification in a sequentially activatable mode. UUU‐DZ‐tFNA achieves in situ UDG detection across multiple biological levels and facilitates risk stratification and drug resistance monitoring of NB ...
Yaqing Lu, Yingyu Zhang, Xianwei Zhang, Mengxin Zhang, Fei Zhang, Jushan Sun, Yahui Yang, Kangbo Liu, Peng Wang, Shuying Luo, Wancun Zhang   +10 more
wiley   +1 more source

Serum transaminase and alkaline phosphatase levels after large doses of norepinephrine and epinephrine in dogs

, 1959
An intravenous infusion in conscious dogs of a large dose of norepinephrine (0.51–0.85 mg/kg) or epinephrine (0.55–0.92 mg/kg) resulted in an elevation in serum glutamic oxalacetic transaminase (SGO-T) which reached a peak in about 6 hours and subsided ...
Harriet M. Maling, Benjamin Highman, Edwin C. Thompson   +2 more
core   +1 more source

Human Alkaline phosphatases in health and disease: A mini review

International Journal of Research in Pharmaceutical Sciences, 2013
Distribution of Alkaline phosphatase (APase) is ubiquitous amongst different cell types and tissues in almost all living organisms. In mammals four isoenzymes with tissue-specific distribution have been well characterized. Several physiological functions
Nageshwari Badgu* , Ramchander Merugu
doaj  

Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition

Advanced Science, EarlyView.
CB1R and ASIC3 are co‐expressed in CGRP+ nociceptors of mouse DRG. Plantar incision triggers an upregulation of ASIC3 and activation of ASIC3+ neurons, driving mechanical allodynia. CB1R activation suppresses ASIC3 function and downstream ERK1/2 phosphorylation, thereby braking nociceptive signaling and accelerating pain resolution.
Kangtai Xu, Luyao Ji, Haoyi Yang, Xiying Chen, Qiaodan Hu, Haimei He, Jiawei Wu, Leyan Shan, Shihui Feng, Yingzhi Li, Xiongchang Tan, Hao Wang, Zilong Wang, Chaoran Wu   +13 more
wiley   +1 more source

What do we know about serum alkaline phosphatase activity as a biochemical bone formation marker?

, 1999
Skeletal alkaline phosphatase, an enzyme localised in the osteoblasts as well as in the extracellular layers of a newly synthesized matrix, is released into the circulation by an unclear mechanism.
Ugar, DA, Karaca, İNCİ RANA
core  

Bone disease in patients with chronic kidney disease under conservative management

São Paulo Medical Journal
CONTEXT AND OBJECTIVE: Few studies have focused on bone disease in patients with chronic kidney disease under conservative treatment. The objective was to evaluate bone disease in patients with chronic kidney disease.
Carlos Perez Gomes, Maria Inês Barreto Silva, Maria Eugênia Leite Duarte, David Dorigo, Carla Cavalheiro da Silva Lemos, Rachel Bregman   +5 more
doaj   +1 more source

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao, Jing Wang, Yankun Li, Haipei Zhang, Yanli Zhang, Qingnian Li, Bo Xiao, Wenhu Zhou, Junhong Guo   +8 more
wiley   +1 more source

In Situ Bioorthogonal Synthesis of PROTACs via Dual‐Responsive Cleavage for Synergistic Photo‐Immunotherapy

Advanced Science, EarlyView.
A bioactive self‐delivering SNAP‐TAC platform responds to tumor‐associated cathepsin B and glutathione, enabling in situ bioorthogonal synthesis of a BRD4‐degrading proteolysis‐targeting chimera within the tumor microenvironment. The resulting BRD4 degradation and PD‐L1 downregulation synergize with photodynamic therapy‐induced immunogenic cell death ...
Shiqin Jian, Jiasha Wu, Fusheng Xu, Yan Zuo, Huaxing Shen, Rui Ji, Luyi Wang, Na Li, Yanting Sun, Yongsheng Yu, Yejiao Shi, Honggang Hu, Feng Xu, Dan Huang, Xiaochun Hu   +14 more
wiley   +1 more source

Engineered Peptide Self‐Assembled Nanofibers for Enhanced STING Activation: A Promising Nanodelivery Platform for Immunotherapy of Pediatric Solid Tumors

Advanced Science, EarlyView.
An engineered peptide self‐assembled nanofiber platform, designed to replicate STING–cGAMP binding motifs, facilitates pH‐responsive cytosolic delivery of cGAMP, enhances the endoplasmic reticulum with high efficiency, and robustly activates the STING pathway.
Yubin He, Xiao Lu, Chang qing Yang, Ran Zhang, Bo Wan, Xin Ni, Dong Mei   +6 more
wiley   +1 more source