Results 101 to 110 of about 181,344 (276)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Penerapan Servant Leadership Di SMP Masa Depan Cerah Surabaya [PDF]

, 2013
Skripsi ini bertujuan untuk mengetahui penerapan servant leadership (mendengarkan, empati, dan konseptualisasi) di SMP Masa Depan Cerah Surabaya. Penulisan ini menggunakan metode kualitatif deskriptif.
Atmaja, Y. W. (Yessica), Sugianto, Y. N. (Yonathan)   +1 more
core  

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Servant leadership and innovative work behavior: Does psychological empowerment matter?

Cogent Business & Management
Using the social exchange theory and Spritzer’s empowerment model, this research explains how servant leadership affects innovative work behavior. There is a lack of empirical evidence on servant leadership’s influence on innovative behavior within the ...
Mercy Wanyana, Ibrahim Abaasi Musenze, Kaziba Abdul Mpaata   +2 more
doaj   +1 more source

Servant Leadership to Toxic Leadership: Power of Influence Over Power of Control [PDF]

, 2014
To lead, you must serve. Servant leadership is the systematic process of developing the needs of servants ahead of those leaders found within private or public institutions.
Exposito, Julie, Matteson, Rande, Ross, David B.   +2 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

PERAN SERVANT LEADERSHIP DALAM MENINGKATKAN KUALITAS PELAYANAN FRONT OFFICE HOTEL GRAND MERCURE MALANG MIRAMA [PDF]

This research aims to find out the role of servant leadership in improving the quality of service at the Front Office of the Grand Mercure Hotel Malang Mirama.
Jefri Irwanda, Irwanda
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source