Results 181 to 190 of about 1,718,808 (353)
Specialized nets of solid-state sensors [PDF]
Tekhnologiya i Konstruirovanie v Elektronnoi Apparature, 2008 The research of the specialized networks based on solid-state sensors with automatic tuning of parameters was carried out. The construction peculiarities of such nets and sensors design used in them were examined.
Kostenko V. L. +2 more
doaj
Server Location Verification and Server Location Pinning: Augmenting TLS Authentication [PDF]
arXiv, 2016 We introduce the first known mechanism providing realtime server location verification. Its uses include enhancing server authentication (e.g., augmenting TLS) by enabling browsers to automatically interpret server location information. We describe the design of this new measurement-based technique, Server Location Verification (SLV), and evaluate it ...
arxiv
Global Heuristic Search on Encrypted Data (GHSED) [PDF]
, 2009 Important document are being kept encrypted in remote servers. In order to retrieve these encrypted data, efficient search methods needed to enable the retrieval of the document without knowing the content of the documents In this paper a technique ...
Halloush, Maisa, Sharif, Mai
core
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
Improving Server Utilization in a Distributed Computing Set-up with Independent Clients [PDF]
arXiv, 2016 We consider a set-up in which there are multiple servers and multiple clients in a large distributed computing system. Clients request servers to process jobs. Servers can only process one job in unit time. There is no coordinating agent to route client requests to servers, and clients choose servers independently and simultaneously, and only have ...
arxiv
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
FEBS Letters, EarlyView.The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang +2 more
wiley +1 more source
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source