Results 301 to 310 of about 1,718,808 (353)

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Advancing Privacy-Preserving Health Care Analytics and Implementation of the Personal Health Train: Federated Deep Learning Study. [PDF]

JMIR AI
Choudhury A, Volmer L, Martin F, Fijten R, Wee L, Dekker A, Soest JV.   +6 more
europepmc   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Molecular dynamic simulations to assess the structural variability of ClpV from <i>Enterobacter cloacae</i>. [PDF]

Front Bioinform
Motiwala T, Nyide B, Khoza T.
europepmc   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

In silico design of Ebola virus Glycoprotein antigenic peptides as vaccine candidates. [PDF]

PLoS One
Lara-Ramírez D, Santacruz-Tinoco CE, Ramón-Gallegos E, Muñoz-Medina JE.   +3 more
europepmc   +1 more source

Efficient IoT User Authentication Protocol with Semi-Trusted Servers. [PDF]

Sensors (Basel)
Hu S, Zhang Y, Guo Y, Zhong W, Chen Y, Chen L.   +5 more
europepmc   +1 more source

GeNIS: A modular dataset for network intrusion detection and classification. [PDF]

Data Brief
Silva M, Pinto D, Vitorino J, Gonçalves J, Maia E, Praça I.   +5 more
europepmc   +1 more source

Tsbrowse: an interactive browser for Ancestral Recombination Graphs

Karthikeyan S, Jeffery B, Mbuli-Robertson D, Kelleher J.   +3 more
europepmc   +1 more source