Results 41 to 50 of about 324,117 (265)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
A Deployment Method of Middlebox Service Chain Based on Multi-Flow Table
Dianxin kexue, 2015 Aiming at the path cycle and source address binding problem in middlebox service chain deployment，a service chain deployment approach by combining the OpenFlow mechanism and NetFPGA was proposed.First of all，the OpenFlow multi-flow table was used for ...
Shiran Liu +3 more
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The interplay between operational supply chain transparency and sustainable supply chain: Does supply chain complexity and business regulatory compliance matter? [PDF]
Modern Supply Chain Research and ApplicationsPurposeThis study examines the relationship between operational supply chain transparency (OSCT) and sustainable supply chains using business regulatory compliance (BRC) as a moderator and supply chain complexity (SCC) as the mediator in manufacturing ...
Prince Amoh Junior +3 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Study on Performance Evaluation of Service Supply Chain by Extension Method
Discrete Dynamics in Nature and Society, 2021 With the rapid development of the service industry, the service supply chain has become one of the most popular areas. With the logistics service supply chain being an important branch of the service supply chain, we should pay attention to the role of ...
Jun Cheng, Qiaoning Yang, Lin Lu
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Discrete particle swarm optimization based multi-objective service path constructing algorithm
Tongxin xuebao, 2017 Aiming at previous research primarily focused on constructing service paths with a single objective,for exam-ple,latency minimization,cost minimization or load balance,which ignored the overall performance of constructed ser-vice paths,a multi-objective ...
Ding MA, Lei ZHUANG, Ju-long LAN
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
A Service Supply Chain Synchronization Model [PDF]
مطالعات مدیریت راهبردی, 2021 Aim and Introduction. The issue of coordination identified as a key management issue in the supply chain. Service supply chain due to its different characteristics, and the products in the service supply chain are service-oriented, complex and more ...
Reza Jalil +2 more
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