Results 61 to 70 of about 1,093,532 (305)

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Book review: Rethinking public service delivery [PDF]

, 2013
Many public services today are delivered by external service providers such as private firms and voluntary organizations. These new ways of working – including contracting, partnering, client co-production, inter-governmental collaboration and ...
Hill, Alastair
core  

The SERVICE Framework: A Public-service-dominant Approach to Sustainable Public Services [PDF]

, 2015
In this paper we argue that the new public management has been a flawed paradigm for public services delivery that has produced very internally efficient but externally ineffective public service organizations.
Alam, Alford, Ashworth, Baden-Fuller, Ball, Baranova, Barraza, Bason, Bekkers, Benington, Benson, Best, Bevir, Bishop, Boozeman, Bovaird, Bovaird, Bovaird, Brown, Bryson, Buchanan, Burton, Chesbrough, Crosby, Dahler-Larsen, Davis, Dawson, Deshpande, Djellal, Dunleavy, Dyer, Echeverri, Elkington, Erridge, Farris, Ferlie, Fledderus, Gains, Gallouj, Gebert, Ghosh, Gray, Grindle, Gronroos, Gronroos, Gronroos, Gulati, Gummesson, Guthrie, Harker, Haveri, Helfert, Holweg, Högström, Jakobsen, Jas, Kale, Kickert, Kinder, Klein, Klijn, Klijn, Kotler, Kotler, Laing, Le Grand, Lovelock, Lusch, Magretta, Margetts, McGuire, McLaughlin, McLaughlin, Meyer, Milward, Mischra, Moore, Muller, Needham, Normann, Osborne, Osborne, Osborne, Osborne, Osborne, Osborne, Osborne, Payne, Pestoff, Pestoff, Phelps, Pirie, Porter, Powell, Powell, Provan, Radnor, Radnor, Radnor, Radnor, Radnor, Reijars, Rhodes, Rhodes, Savas, Schwartz, Shostack, Skalen, Sorin, Stoker, Stone, Surjadjaja, Vamstad, Van Eijk, Veloutsou, Verma, Verschuere, Vidal, Von Hippel, Von Hippel, Walsh, Williamson, Wistow, Womack, Xue, Zott   +125 more
core   +4 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Shared geriatric mental health care in a rural community [PDF]

, 2007
Introduction: A pilot project in shared mental health care was initiated to explore opportunities to increase the capacity of the rural primary care system as a resource for older people with mental health needs.
Dolansky, D, Le Clair, JK, Leon, S, Parenteau, P, Sullivan, MP   +4 more
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

A One Health framework for integrated service delivery in Turkana County, Kenya

Pastoralism, 2020
Pastoralists in sub-Saharan Africa have limited access to public services due to their mobile lifestyle, economic and political marginalization, and the limited health infrastructure that is common to arid and semi-arid lands (ASALs) where they primarily
Evan F. Griffith, Job Ronoh Kipkemoi, Alison H. Robbins, Tequiero O. Abuom, Jeffrey C. Mariner, Tabitha Kimani, Hellen Amuguni   +6 more
doaj   +1 more source

Optimized Network-coded Scalable Video Multicasting over eMBMS Networks [PDF]

, 2015
Delivery of multicast video services over fourth generation (4G) networks such as 3GPP Long Term Evolution-Advanced (LTE-A) is gaining momentum. In this paper, we address the issue of efficiently multicasting layered video services by defining a novel ...
Chatzigeorgiou, Ioannis, Jones, Andrew L., Tassi, Andrea, Vukobratović, Dejan   +3 more
core   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Intelligent multimedia communication for enhanced medical e-collaboration in back pain treatment [PDF]

, 2004
This is the post-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2004 SAGE PublicationsRemote, multimedia-based, collaboration in back pain treatment is an option which only recently has come
Frank, AO, Ghinea, G, Magoulas, GD
core   +1 more source