Results 111 to 120 of about 4,707,888 (270)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Service Design of a Loss Prevention Device for Older Adults with Dementia. [PDF]

Geriatrics (Basel), 2023
Hsu CK, Liu CC, Chang T, Liao JJ, Shu CM.   +4 more
europepmc   +1 more source

Proceedings of the 4th International Conference on Service Life Design for Infrastructure (SLD4) [PDF]

, 2018
SLD4 is a conference on Service Life Design for Infrastructures which is jointly organised by Delft University and Tongji University as part of the RILEM week 2018 in Delft, The Netherlands.
Rodriguez, Claudia Romero, Savija, Branko, Ye, Guang, Yuan, Yong, Zhang, Hongzhi   +4 more
core  

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Using Co-Design to Adapt a Digital Parenting Program for Parents Seeking Mental Health Support

Children
Background/Objectives: Parental mental health challenges are associated with parenting difficulties and child mental health issues. Parenting interventions can support families; however, parents with mental health challenges face barriers to accessing ...
Meg Louise Bennett, Ling Wu, Joshua Paolo Seguin, Patrick Olivier, Andrea Reupert, Anthony F. Jorm, Sylvia Grant, Helen Vaxevanis, Mingye Li, Jue Xie, Marie Bee Hui Yap   +10 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

INTEGRATION OF SERVICE LIFE IN THE PROCESS OF MANAGEMENT AND DESIGN OF BUILDINGS [PDF]

This article approaches the regulatory framework on the service life of constructed assets and its integration into the management and design process of sustainable buildings.
Silverio HERNÁNDEZ-MORENO
core  

Service life design for infrastructure [PDF]

, 2010
In the past few years more and more attention has been devoted to the safety and serviceability as well as durability and sustainability of structures. Meanwhile there are intensive research and development activities going on, e.g.
van Breugel, K, Ye, Guang, Yuan, Yong
core   +1 more source