Results 91 to 100 of about 1,018,999 (294)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

SFP selection algorithm for SFC

Dianxin kexue, 2017
In order to achieve the new business deployment model by the convergence of cloud and network,SFC technology has been promoted greatly.As one of the key technologies in SFC,the SFP selection strategy affects the network performance and business ...
Yongqing ZHU, Xia GONG, Huanan CHEN
doaj   +2 more sources

Bayesian control of the number of servers in a GI/M/c queuing system [PDF]

, 2004
In this paper we consider the problem of designing a GI/M/c queueing system. Given arrival and service data, our objective is to choose the optimal number of servers so as to minimize an expected cost function which depends on quantities, such as the ...
Ausín Olivera, María Concepción, Lillo Rodríguez, Rosa Elvira, Wiper, Michael Peter   +2 more
core   +1 more source

A Scalable Approach for Service Chain (SC) Mapping with Multiple SC Instances in a Wide-Area Network

, 2017
Network Function Virtualization (NFV) aims to simplify deployment of network services by running Virtual Network Functions (VNFs) on commercial off-the-shelf servers.
Gupta, Abhishek, Jaumard, Brigitte, Mukherjee, Biswanath, Tornatore, Massimo   +3 more
core   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

AutoVNF: An Automatic Resource Sharing Schema for VNF Requests

Journal of Internet Services and Information Security, 2019
Nowadays, network function virtualization (NFV) receives widespread concerns from the whole society for its promising application. The main challenge for the deployment of VNF that comes along is the resource allocation of demanded network services in ...
Wei Huang, Haoren Zhu, Zhuzhong Qian
doaj   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Resource optimization algorithm of combination of NFV and SDN for application of multiple services

Tongxin xuebao, 2018
Various services of internet of things (IoT) require flexible network deployment to guarantee different quality of service (QoS).Aiming at the problem of IoT service function chain deployment,network function virtualization (NFV) and software defined ...
Xiaorong ZHU, Qian ZHANG
doaj   +2 more sources

A survey on service function chaining

Journal of Network and Computer Applications, 2016
Cloud computing is gaining significant attention and virtualized datacenters are becoming popular as a cost-effective infrastructure. The network services are transitioning from a host-centric to a data-centric model moving the data and the computational resources closer to the end users.
Bhamare, Deval, Jain, Raj, Samaka, Mohammed, Erbad, Aiman   +3 more
openaire   +3 more sources