Results 231 to 240 of about 11,069,622 (290)

Exploring meaningful outcome domains of recovery following lower limb amputation (LLA) and prosthetic rehabilitation in low- and middle-income (LMIC) settings: a qualitative systematic review. [PDF]

BMJ Open
Fewins CJ, Ostler C, Donovan-Hall M.
europepmc   +1 more source

A Hepatocyte‐to‐Stellate Cell Axis Couples Alternate‐Day Fasting to Liver Fibrosis Resolution via ATG7 S‐Nitrosylation

Advanced Science, EarlyView.
Alternate‐day fasting suppresses mitochondrial complex II assembly via SDHAF4 to upregulate hepatocyte eNOS. The resulting nitric oxide S‐nitrosylates ATG7 at C184 in hepatic stellate cells, restraining autophagic flux and preventing their profibrotic activation.
Xueqiang Wang, Mengqi Zeng, Cunxiao Sun, Yuhan Gou, Zhaode Feng, Weiqiang Lv, Chaoying Yan, Hansen Wu, Pengfei Zhang, Jie Xu, Ke Cao, Hao Li, Mingge Ding, Zhongbo Liu, Xing Zhang, Jiankang Liu, Xuan Zou, Zhihui Feng   +17 more
wiley   +1 more source

VACmap: an accurate long-read aligner for unraveling complex genomic rearrangements. [PDF]

Nat Commun
Ding H, Sedlazeck FJ, Proukakis C, Morley C, Toffoli M, Schapira AH, Liao Z, Pu L, Zhu S.   +8 more
europepmc   +1 more source

Compound Abrus cantoniensis Extract Alleviates AFB1‐Induced Liver Injury by Regulating PI3K‐AKT Pathway and Gut Microbiota/Butyrate Metabolism

Advanced Science, EarlyView.
ACCE has a good alleviating effect on AFB1‐induced liver injury, and this alleviating effect is related to the PI3K‐AKT pathway regulated by ACCE and the butyrate metabolism of gut microbiota. ABSTRACT Aflatoxin B1 (AFB1) is a potent hepatotoxin commonly ingested through contaminated food. Abrus cantoniensis Hance, a traditional Chinese medicinal herb,
Hongjie Hu, Ming cheng, Shiqi Zheng, Huixin Liu, Xiaofang Wei, Wenwen Yang, Hongchun Yang, Liuyang Yuan, Li Jiang, Jie Chen, Linglong Zhao, Yanchao Guo, Hongbin Si   +12 more
wiley   +1 more source

Systemic Transcriptional Responses to Clinical Vaccine Formulations and Live-Attenuated Vaccination: Comparative Kinetics and Hypotheses for Therapeutic Cancer Vaccine Monitoring. [PDF]

Vaccines (Basel)
Goldman CK.
europepmc   +1 more source

Salvianolic Acid a Disrupts the HSP90α‐AKT‐PERK Ternary Complex to Alleviate Atherosclerosis by Activating Endoplasmic Reticulum Stress of Senescent Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Salvianolic acid A (SAA) selectively induces senescent vascular smooth muscle cell apoptosis, alleviating atherosclerosis. Mechanistically, SAA targets heat shock protein 90 alpha (HSP90α) to disrupt the protein inase B (AKT)‐PRKR‐Like Endoplasmic Reticulum Kinase (PERK) scaffold, driving ubiquitin‐proteasome‐dependent AKT degradation.
Xiuya Guan, Mengkai Lu, Xinhai Cui, Dawei Zhang, Lei Zhang, Lin Lin, Yuan Li, Yuanlong Hu, Chao Li   +8 more
wiley   +1 more source

Psychological Frailty in Later Life: A Critical Narrative Review of Integrative Interventions and the Proposed RESERVE-7 Heuristic. [PDF]

Healthcare (Basel)
Ibrahim FM, Shahrour G, Elbarbary K.
europepmc   +1 more source

War-Related PTSD and Its Impact on Neuroendocrine Function, Immune Dysregulation, and Growth in Children: Implications for Syrian Children. [PDF]

Avicenna J Med
Sultan B, Tayade SD, Jadhav R.
europepmc   +1 more source

Neurodiversity as an epistemic stress test for psychotherapy and health care: a neuroaffirmative conceptual analysis of relational-proximity priors in clinical, institutional, and AI-supported models. [PDF]

Front Psychiatry
Niederlohmann E.
europepmc   +1 more source

A study of blockchain-based liquidity cross-chain model. [PDF]

PLoS One
Han Y, Wang C, Wang H, Yang Y, Wang X.
europepmc   +1 more source