Results 91 to 100 of about 2,140,872 (281)

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Aligning HIV treatment and hypertension clinic visits and dispensing as a first step towards service delivery integration in South Africa

Journal of the International AIDS Society
Introduction Global and national guidelines recommend the integration of care for HIV and other chronic conditions to improve individual and public health outcomes.
Oratile Mokgethi, Amy Huber, Idah Mokhele, Khumbo Shumba, Vinolia Ntjikelane, Sydney Rosen, Sophie Pascoe   +6 more
doaj   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

How did New Zealand's regional District Health Board groupings work to improve service integration and health outcomes: a realist evaluation. [PDF]

BMJ Open, 2023
Penno E, Atmore C, Maclennan B, Richard L, Wyeth E, Richards R, Doolan-Noble F, Gray AR, Sullivan T, Gauld R, Stokes T.   +10 more
europepmc   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Collective Competence as an Enabler for Service Integration in Health and Social Care Services. [PDF]

J Multidiscip Healthc, 2022
Løken TD, Helgesen MK, Bjørkquist C.
europepmc   +1 more source

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

Aging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath, Mathigatta Shivarudraiah S, Rajath Govind, Kaushik M R   +3 more
wiley   +1 more source

Integrating Mental Health Services Into Perinatal Care: Challenges and Opportunities

Journal of Multidisciplinary Healthcare
Garumma T Feyissa,1 Enrique R Pouget,1 Sena B Kitila,2 Yonas Biratu Terfa,2 Tracy Wong1 1Department of Health and Nutrition Sciences, Brooklyn College, City University of New York, Brooklyn, NY, 11210, USA; 2School of Nursing, Institute of Health, Jimma ...
Feyissa GT, Pouget ER, Kitila SB, Terfa YB, Wong T   +4 more
doaj  

Parlay and OGSA based framework for service creation in NGN

Tongxin xuebao, 2007
A parlay and open grid services architecture（OGSA） based framework for service creation in NGN was pro-posed,which not only provided uniform access to heterogeneous network capabilities,but also built effective distributed convergence mechanisms beyond ...
LIU Zhen1, YANG Jing 2, LI Guo-jie2, ZHANG Guo-qing2   +3 more
doaj  

An analysis of the possible causes of product market malfunctioning in the EU: First results for manufacturing and service sectors [PDF]

Within the context of the follow-up to the Single Market Review, the European Commission has screened EU manufacturing and service sectors for problems of market malfunctioning. This paper investigates the nature of these problems in the selected sectors
Adriaan Dierx, Fabienne Ilzkovitz, Nuno Sousa   +2 more
core