Results 41 to 50 of about 2,140,872 (281)

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Adaptive service discovery on service-oriented and spontaneous sensor systems [PDF]

, 2012
Service-oriented architecture, Spontaneous networks, Self-organisation, Self-configuration, Sensor systems, Social patternsNatural and man-made disasters can significantly impact both people and environments.
Antonopoulos, Nikolaos, Li, Jianxin, Liu, Lu, Wu, Kaigu, Xu, Jie   +4 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Integrating a single-dose intravenous iron therapy (ferric carboxymaltose) for maternal anaemia in Nigeria: Insights from stakeholder engagement

Journal of Public Health in Africa
Background: Maternal anaemia contributes to high maternal morbidity and adverse birth outcomes in Nigeria. Oral iron supplementation is common but limited by poor adherence, side effects and systemic barriers.
Rachel A. Thompson, Uchenna Gwacham-Anisiobi, Chisom Obi-Jeff, Mobolanle Balogun, Opeyemi R. Akinajo, Esther Oluwole, Yusuf Adelabu, Temitope Audu, Bosede B. Afolabi, Aduragbemi Banke-Thomas   +9 more
doaj   +1 more source

The evaluation of educational service integration in integrated virtual courses [PDF]

, 2001
The effectiveness of an integrated virtual course is determined by factors such as the navigability of the system. We argue that in a virtual course, which offers different educational services for different learning activities, the integration of ...
Pahl, Claus
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

How should comparative health reporting be designed in order to make it readily understandable? Thoughts and ideas to develop a health barometer for the Baden-Württemberg Health Map [PDF]

Journal of Health Monitoring, 2017
Baden-Württemberg’s Ministry for Social Affairs and Integration commissioned the Mannheim Institute for Public Health to develop an instrument which would enable health comparisons based on an analysis of strengths and weaknesses at the federal and ...
Anne Würz
doaj   +1 more source

Knowledge modelling for integrating semantic web services in e-government applications [PDF]

, 2005
Service integration and domain interoperability are the basic requirements in the development of current service-oriented e-Government applications. Semantic Web and, in particular, Semantic Web Service (SWS) technology aim to address these issues ...
Cabral, Liliana, Domingue, John, Gugliotta, Alessio   +2 more
core  

Supporting Semantically Enhanced Web Service Discovery for Enterprise Application Integration [PDF]

, 2009
The availability of sophisticated Web service discovery mechanisms is an essential prerequisite for increasing the levels of efficiency and automation in EAI.
Kourtesis, Dimitrios, Paraskakis, Iraklis   +1 more
core   +1 more source