Results 51 to 60 of about 2,140,872 (281)
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Australian and New Zealand Journal of Public Health, 2020 Objective: To assess the feasibility and acceptability of integrating a contraception clinic within an opioid agonist treatment (OAT) service to improve access to contraception, especially long‐acting reversible methods of contraception (LARC), for women
Carolyn A. Day +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
A conceptual model for semantically-based e-government portals [PDF]
, 2005 Issues of semantic interoperability and service integration for e-government portals are the domain of interest of the present paper. We propose a Conceptual Model for One-Stop e-Government Portals based on the Semantic Web Service technology.
Cabral, Liliana +3 more
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Distributed aspect-oriented service composition for business compliance governance with public service processes [PDF]
, 2010 Service-Oriented Architecture (SOA) offers a technical foundation for Enterprise Application Integration and business collaboration through service-based business components.
Bandara, Kosala Yapa +2 more
core +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Вестник Северо-Кавказского федерального университета, 2022 Formalized the task of developing the service integration of software components of a distributed system OSS|BSS communications operator model of integration is presented in the form of a multiphase queuing system, the dependences of the busy period of ...
Dmitrij Valerevich Mochalov
doaj
Design Opportunities in Service-Product Combined Systems [PDF]
, 2009 This paper aims to examine recent research issues related to the integration of service and product in view of industrial design. Further, it attempts to identify new opportunities for further research regarding “product-servicization” vs.
Jung, Mi-Jin, Nam, Ki-Young
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source