Results 71 to 80 of about 2,135,754 (281)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Social Work and Society, 2013 European migration law combines equal treatment within Europe and unequal treatment at the borders, while local migration policy aims at social inclusion, acceptance of diversity and equality.
Anja Van den Durpel
doaj
, 2018 The purpose of this paper is to propose viewpoints for analysing well-being oriented value co-creation. We firstly explain the concept of transformative service research: TSR which centres on consumer well-being in service and discuss its importance in ...
ホー, バック, 白肌, 邦生
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Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Service Integration: Supply Chain Integration in Servitization
, 2021 Research and empirical evidence indicates that servitization changes the traditional manufacturing supply chain. Firms engaged in servitization must integrate with a network of actors ranging from component suppliers to intermediaries to customers. To develop a comprehensive picture of supply chain integration in the servitization context, this chapter
openaire +3 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Attitudinal and behavioural determinants influencing decision makers when adopting integration technologies in local government [PDF]
, 2010 Over the last few years, the advent of innovative or revolutionary integration technologies has influenced pivotal decisions within top management to strategically transform Local Government Authorities (LGAs).
Irani, Z, Kamal, M, Weerakkody, V
core +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Inter-Domain Integration of Services and Service Management
, 1997 The evolution of the global telecommunications industry into an open services market presents developers of telecommunication service and management systems with many new challenges.
Bracht, Ralf +5 more
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Design Opportunities in Service-Product Combined Systems [PDF]
, 2009 This paper aims to examine recent research issues related to the integration of service and product in view of industrial design. Further, it attempts to identify new opportunities for further research regarding “product-servicization” vs.
Jung, Mi-Jin, Nam, Ki-Young
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