Results 101 to 110 of about 54,878 (303)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
PROBLEMS AND PROSPECTS OF INTERNATIONAL TRADE LICENSES IN UKRAINE
Ekonomìčnij Vìsnik Nacìonalʹnogo Tehnìčnogo Unìversitetu Ukraïni "Kiïvsʹkij Polìtehnìčnij Institut", 2015 It was analysed international trade licenses on a global level, determined country and sector, which occupy a significant share of the market license.
Алла Рашидівна Дунська +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Service Level Agreements: Web Services and Security [PDF]
, 2007 To support the quality of service guarantee from the service provider side, complex web services require to be contracted through service level agreement. State of the art on web services and web service compositions provides for a number of models for describing quality of service for web services and their compositions, languages for specifying ...
openaire +3 more sources
On-Line Control of Service Level Agreements [PDF]
, 2006 Service Level Agreement (SLA) is used as the comer stone for building service quality management (SQM) systems. SLA and the processes associated with them, establish a two-way accountability for service, which is negotiated and mutually agreed upon, by customer and service provider.
Manoel Camillo Penna +1 more
openaire +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Language support for service-level agreements for application-service provision
, 2007 My thesis is that practical language support can be provided for Service-Level Agreements (SLAs) for Application-Service Provision (ASP), which is better than that provided by pre-existing languages in that: it provides greater assistance in expressing
Skene, J.
core
Securing Packet and Optical Transport Connectivity Services in Multi-Stakeholder Untrusted Networks
IEEE Open Journal of the Communications SocietyThis paper presents a security and trust solution for 6G transport networks, focusing on the integration of Distributed Ledger Technology (DLT), Closed-Loop (CL) automation, and trust-based security management across multi-domain, multi-provider ...
Pol Alemany +14 more
doaj +1 more source
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source