Results 101 to 110 of about 13,114,410 (297)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Web Hosting Service Level Agreements [PDF]

, 2001
This paper proposes a model for a relatively simple Web hosting provider. The model assumes the existence of a load-dispatcher and a finite number of Web-servers.
King, Alan
core  

Service Level Agreements for Cloud Computing

, 2011
Service Level Agreements for Cloud Computing provides a unique combination of business-driven application scenarios and advanced research in the area of service-level agreements for Clouds and service-oriented infrastructures.
Theilmann, Wolfgang, Butler, Joe M., Wieder, Philipp, Yahyapour, Ramin   +3 more
core   +1 more source

Service Level Agreements: Web Services and Security [PDF]

, 2007
To support the quality of service guarantee from the service provider side, complex web services require to be contracted through service level agreement. State of the art on web services and web service compositions provides for a number of models for describing quality of service for web services and their compositions, languages for specifying ...
openaire   +3 more sources

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Flexible and dynamic SLAs management in Service Oriented Architectures

, 2011
The increasing adoption of service oriented architectures across different administrative domains forces service providers to use effective mechanisms and strategies of resource management in order for them to be able to guarantee the quality levels ...
Orazio Tomarchio, Giuseppe Di Modica, Di Modica G, Tomarchio O   +3 more
core   +1 more source

Securing Packet and Optical Transport Connectivity Services in Multi-Stakeholder Untrusted Networks

IEEE Open Journal of the Communications Society
This paper presents a security and trust solution for 6G transport networks, focusing on the integration of Distributed Ledger Technology (DLT), Closed-Loop (CL) automation, and trust-based security management across multi-domain, multi-provider ...
Pol Alemany, Mattin Antartiko Elorza Forcada, Sergiy Remezov, Miriam Castro, Diogo Nogueira, Ricard Vilalta, Lluis Gifre, Javier Jose Diaz, Antonio Pastor, Guillermo Gomez, Sonia Castro, Jose Cunha, Javier Garcia, Alberto Gonzalez Barneo, Raul Munoz   +14 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source