Results 71 to 80 of about 11,765,691 (288)

Measuring. Monitoring. Management. Control

Измерение, мониторинг, управление, контроль
Background. The article analyzes the works devoted to existing approaches to substantiating the service life of complex technical systems. Materials and methods.
E.A. Mikhaylov, V.I. Mishchenko, A.P. Permyakov   +2 more
doaj   +1 more source

Responses of Flexible Pavement Structure to Variation of Load Type, Material Characteristics, and Service Life using Kenlayer Program

Jurnal Teknik Sipil, 2019
One of the pavement types often used in Indonesia is flexible pavement. Many methods and programs can be used for flexible pavement structure analysis, such as analytical method using Kenlayer program.
Kardina Nawassa Setyo Ayuningtyas, Bambang Sugeng Subagio   +1 more
doaj  

INTEGRATION OF SERVICE LIFE IN THE PROCESS OF MANAGEMENT AND DESIGN OF BUILDINGS [PDF]

This article approaches the regulatory framework on the service life of constructed assets and its integration into the management and design process of sustainable buildings.
Silverio HERNÁNDEZ-MORENO
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Prediction of Bearing Service Life Using an Auto Regression Moving Average and Response Surface Methodology

Applications of Modelling and Simulation, 2022
Accurate prediction of service life of machines and their components is very important for reliability evaluation, and efficiency. It is intended in the current work to introduce a method to predict service life of bearings using accelerated life test ...
Dalia M. Ammar, Samy E. Oraby, Mohammad A. Younes, Elsayed S. Elsayed   +3 more
doaj  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Remaining Service Life Asset Measure, Phase 1

, 2018
There is a critical need to use a common metric, such as a service life parameter, across many different types of infrastructure assets. MnDOT has used the remaining service life (RSL) measure for pavement condition for several years and is starting to ...
Kumar, Ravi, Marasteanu, Mihai, Matias de Oliveira, Jhenyffer, Schultz, Arturo   +3 more
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Health Service Executive National Service Plan 2012

, 2012
Under the legislative framework of the Health Act, 2004, Section 31, the primary purpose of the annual HSE National Service Plan (NSP) is to set out how the Estimate (budget) allocated to the HSE will be spent in the given year on the type and volume of ...
Health Service Executive (HSE)
core