Results 61 to 70 of about 5,062,372 (328)

Support for incident management in optical networks through critical points identification

Ingeniería e Investigación, 2019
In incident management for optical networks, when a fault or event occurs, a network element will often send a notification, in the form of an “alarm”, to operators and managers. Alarms contain valuable information to support the fault management process
Aminadabe Barbosa de Sousa, Alberto Sampaio Lima, José Neuman de Souza, José Antão Beltrão Moura   +3 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Multi-service management in a multi-provider environment

, 1995
As the spread of digital networks makes access to data communications globally available, the interest of communication service providers is switching away from the provision of these bearer networks and towards the provision of the value added services ...
Lewis, David, Tiropanis, Thanassis
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Challenges in Managing Public Library Services Aimed at Ensuring the Well-being of Society in the Context of Emergency Situations

Social Welfare: Interdisciplinary Approach
The paper analyses the challenges of managing public library services in the context if emergencies in order to sustain public library services and thus contribute to the well-being of society.
Diana Šaparnienė, Kristina Kulikauskienė, Neringa Aleksandravičiūtė, Virginija Miežinienė   +3 more
doaj   +1 more source

Meeting the challenges of urban park management: A Study of Two Sites: a thesis completed and submitted in partial fulfilment of the requirements for the degree of Master of Philosophy in Resource and Environmental Planning, Massey University, Palmerston North, New Zealand [PDF]

, 2001
There are key environmental and management issues relevant to protected areas and national parks apparent world-wide such as: management of environmental quality, biodiversity conservation, management of visitor use and impacts, allocation of access, law
Maling-Emana, Maria Theresa Salvacion
core  

Process Management in Distributed Operating Systems [PDF]

, 1987
As part of designing and building the Amoeba distributed operating system, we have come up with a simple set of mechanisms for process management that allows downloading process migration, checkpointing, remote debugging and emulation of alien operating ...
Mullender, Sape J.
core   +3 more sources

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Architecture Transformation: Integrating Smart Systems for Intelligent Agent-Based Service Management in Smart Organizations

IEEE Access
In the pursuit of organizational goals, addressing the fundamental needs of employees, such as ensuring the availability of drinking water, plays a pivotal role in fostering a productive, healthy, and value-aligned work environment.
Ary Setijadi Prihatmanto, Agus Sukoco, Agus Budiyono, Dewi Tresnawati, Nina Lestari, Husni Teja Sukmana, Ummu Atiah, Sri Wahyuni, Wahida Ratnawati, Ketut Abimanyu Munastha   +9 more
doaj   +1 more source