Results 51 to 60 of about 981,793 (347)

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

open access: yesFEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer   +10 more
wiley   +1 more source

An intervention to improve provider-patient interaction at methadone maintenance treatment in China. [PDF]

open access: yes, 2019
BackgroundThis study evaluated an intervention aiming to improve methadone maintenance therapy (MMT) service providers' interaction with their patients in China.MethodsSixty-eight MMT clinics were randomized to either an intervention or a control ...
Cao, Wei   +5 more
core  

Mapping the evolution of mitochondrial complex I through structural variation

open access: yesFEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin   +2 more
wiley   +1 more source

Client Provider Collaboration for Service Bundling

open access: yesAdvances in Electrical and Computer Engineering, 2008
The key requirement for a service industry organization to reach competitive advantages through product diversification is the existence of a well defined method for building service bundles.
LETIA, I. A., MARGINEAN, A.
doaj   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

open access: yesFEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur   +5 more
wiley   +1 more source

Working Report #1: Service Model Accessibility (Service Provider Perspectives) [PDF]

open access: yes, 2009
This report examines the differences in service accessibility across central, integrated, and school/community based child welfare service delivery models including geographic proximity to families, acceptability of the setting to families, and ...
Cameron, Gary, Hazineh, Lirondel
core   +1 more source

Multi-service management in a multi-provider environment

open access: yes, 1995
As the spread of digital networks makes access to data communications globally available, the interest of communication service providers is switching away from the provision of these bearer networks and towards the provision of the value added services ...
Lewis, David, Tiropanis, Thanassis
core   +1 more source

Exploring the possibility of MaaS service in Thailand, implications from the existing conditions and experts' opinions on “Who should be the MaaS provider in Bangkok?”

open access: yesIATSS Research, 2019
Mobility-as-a-Service or MaaS is the emerging transport solution that services a package of mobility to customers. MaaS aims to give a new travel experience to travelers, in terms of access to the services and seamless trips on one single platform.
Sorawit Narupiti
doaj   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

open access: yesMolecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

User involvement and desired service developments in drug treatment: Service user and provider views [PDF]

open access: yes, 2007
Aims - To investigate the existing level of user involvement at selected agencies, to examine views about user involvement from both service-user and provider perspectives and to compare desired service developments.
Beresford P   +12 more
core   +1 more source

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