Results 61 to 70 of about 5,237,638 (308)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

المسؤولية المدنية لمقدمي خدمات الأمن السيبراني. [PDF]

open access: yesمجلة البحوث القانونية و الاقتصادية
هدفت الدارسة إلى بيان المسؤولية المدنية لمقدمي خدمات الأمن السيبراني من خلال استخدام المنهج الوصفي التحليلي في هذه الدراسة والمنهج المقارن بين القوانين ذات العلاقة، وتتمحور مشكلة الدراسة في بيان المسؤولية المدنية لمقدمي خدمات الأمن السيبراني من خلال ...
أحمد هشام فواز العمري
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Web Service Providers\' Game on Price and Service Level

open access: yesInternational Journal of Industrial Engineering and Production Research, 2010
Response time is one of the critical web service quality dimensions. It refers to how long it takes that a web service responds to request of a user. In order to manage the response time, pricing schemes can work as an efficient access control mechanism.
Ali Habibi Badrabadi   +1 more
doaj  

Valuing Publicly Provided Services [PDF]

open access: yesEconomic Record, 2001
Decisions about expenditure on health, education and other publicly provided services require choices regarding how much of our collective income we should allocate to these services and which services should be given priority. The attempt to answer this question has stimulated many developments in economic theory and practice, from human capital ...
openaire   +5 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Older transgender women in Thailand: views of service providers

open access: yes, 2019
The social and cultural construction of aging and how it is experienced by transgender women in Thailand has been neglected within the academic literature. This qualitative study explored how Thai lesbian, gay, bisexual, transgender, and intersex (LGBTI)
Hair, Sara Amy   +3 more
core   +1 more source

Global knowledge/local bodies: Family planning service providers' interpretations of contraceptive knowledge(s)

open access: yesDemographic Research, 2008
Contraceptive technologies and the knowledges that are constructed around them are simultaneously global and local. Family planning methods in the context of international development interventions are interpreted and understood as part of the ...
Lisa Ann Richey
doaj  

Socio-ecological influences on sexual and reproductive health service use: Young adults and provider perspectives from Soshanguve, South Africa

open access: yesAfrican Journal of Primary Health Care & Family Medicine
Background: Despite widespread availability of sexual and reproductive health (SRH) services and educational initiatives in South Africa, risky sexual behaviours, including unprotected sex, remain prevalent among young adults. These behaviours drive high
Naum M. Maeko   +2 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

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