Results 101 to 110 of about 11,982,422 (300)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Molecular and gene expression analyses of chicken oncomodulin and their association with breast myopathies in broilers

Poultry Science
: Oncomodulins (OCMs), also known as non-α-parvalbumins, are small molecules known for their high-affinity binding of Ca2+ ions. They play crucial roles as Ca2+ buffers and participate in signaling pathways within muscle and neuron cells.
Byungwhi Kong, Majid Shakeri, Janghan Choi, Hong Zhuang, Brian Bowker   +4 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Measuring IT service quality: evaluation of IT service quality measurement framework in industry

, 2014
IT service quality is determined by the value that the IT service brings to both the IT service provider and its customers, but service value is not measured in most IT service organizations today.
Lepmets, Marion, Cater-Steel, Aileen
core   +1 more source

Integrated trouble management to support service quality assurance in a multi-provider context [PDF]

, 2000
Liberalisation of telecommunications encourages competition between the various actors in the Open Service Market (OSM). In this highly competitive context, Connectivity Service Providers (CSPs) and Value Added Service Providers (VASPs) are investigating
Wilhelm Vortisch, Vortisch, W., Dan Dragan, Dragan, D., Tschichholz, M., Hall, Jane, Jane Hall, Michael Tschichholz, Hall, J., Dragan, Dan, SINNOTT, RICHARD, Vortisch, Wilhelm, Richard Sinnott, Sinnott, R.O., Gringel, T., Tschichholz, Michael, Gringel, Thomas, Thomas Gringel, Sinnott, R.   +18 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Service quality in Riyadh's elite hotels: Measurement and evaluation

, 2002
Previous research has offered several models for conceptualizing service quality, the best known of which is the disconfirmation model as expressed by the SERVQUAL scale.
Alzaid, Anas Abdullah, Soliman,Ahmed Ali
core  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

A FUZZY DECISION MAKING APPROACH IN EVALUATING FERRY SERVICE QUALITY [PDF]

The service quality evaluation is undeniably important especially in highly competitive service related industry. However, service quality evaluation is not always straightforward as criteria in evaluation and customer perceptions toward services are ...
Nurhanadia WAHAB, Lazim ABDULLAH
core