Results 61 to 70 of about 12,587,509 (357)

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

The impact of a hospital electronic prescribing and medication administration system on medication administration safety: an observational study

BMC Health Services Research, 2017
Background The aim of the study was to explore the impact of the implementation of an electronic prescribing and medication administration system (ePA) on the safety of medication administration in an inpatient hospital setting.
Seetal Jheeta, Bryony Dean Franklin
doaj   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Validation of a French version of the empowerment scale for mental health service users

BMC Psychiatry
Background As the concept of empowerment is increasingly adopted across various mental health care contexts, there is a growing need for standardized measures to assess the effectiveness of empowerment approaches. The Empowerment Scale is widely utilized
Saphir Desvignes, Mohamed Boucekine, Sandrine Loubière, Léa Leclerc, Pascal Auquier, Aurélie Tinland   +5 more
doaj   +1 more source

Quality of security service

Proceedings of the 2000 workshop on New security paradigms, 2001
Abstract : We examine the concept of security as a dimension of Quality of Service in distributed systems. Implicit to the concept of Quality of Service is the notion of choice or variation. Security services also offer a range of choice both from the user perspective and among the underlying resources.
Irvine, Cynthia E., Levin, Timothy E.
openaire   +3 more sources

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

What impact did the COVID-19 pandemic have on hospital complaints? A 7-year retrospective study in a Swiss public hospital

BMC Health Services Research
Background Patient dissatisfaction frequently results in formal complaints, which can reveal critical issues related to care quality, communication, and organizational performance.
Angela Greco, Riccardo Bocci, Hans Stricker, Stefano Lucchina   +3 more
doaj   +1 more source

The FireWork v2.0 air quality forecast system with biomass burning emissions from the Canadian Forest Fire Emissions Prediction System v2.03 [PDF]

Geoscientific Model Development, 2019
Biomass burning activities can produce large quantities of smoke and result in adverse air quality conditions in regional environments. In Canada, the Environment and Climate Change Canada (ECCC) operational FireWork (v1.0) air quality forecast system ...
J. Chen, K. Anderson, K. Anderson, R. Pavlovic, M. D. Moran, P. Englefield, D. K. Thompson, R. Munoz-Alpizar, H. Landry   +8 more
doaj   +1 more source

Higher education service quality, student satisfaction and loyalty

Quality Assurance in Education, 2019
Purpose The purpose of this study is to validate the higher education service quality (HESQUAL) scale using a confirmatory approach and test an improved structural model that predicts student loyalty from image, perceived value, satisfaction and service
Viraiyan Teeroovengadum, R. Nunkoo, C. Grönroos, T. Kamalanabhan, A. Seebaluck   +4 more
semanticscholar   +1 more source