Results 131 to 140 of about 563,218 (303)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

To tell the right story : Functions of the personal user narrative in service user involvement

Journal of Comparative Social Work, 2015
From the starting point of narrative ethnography, this article explores a specific kind of service user involvement in psychiatry: staff training activities in which patients and former patients are invited to “tell their stories”.
Erik Eriksson
doaj  

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Three strategies of user participation. Interest organisation representatives’ views on how they make an impact on service development

Nordic Social Work Research
This paper explores user participation in interest organizations that represent people in vulnerable life situations and addresses the following research question: How do interest organizations seek to influence public actors, and what are the perceived ...
Jan Marius Gathen, Tor Slettebø, Erik Skjeggestad   +2 more
doaj   +1 more source

Public involvement in alcohol research. [PDF]

, 2017
In late 2016, Alcohol Research UK initiated a programme of work exploring public involvement in alcohol research. Over the following months, we ran a series of national events with service providers, research leaders, funding bodies, academics, and ...

core  

Optimizing Wirelessly Powered Crowd Sensing: Trading energy for data

, 2017
To overcome the limited coverage in traditional wireless sensor networks, \emph{mobile crowd sensing} (MCS) has emerged as a new sensing paradigm. To achieve longer battery lives of user devices and incentive human involvement, this paper presents a ...
Andreev, Sergey, Gong, Yi, Huang, Kaibin, Li, Xiaoyang, You, Changsheng   +4 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Continuance intention and digital health resources from the perspective of elaboration likelihood model and DART model: a structural equation modeling analysis

Frontiers in Public Health
BackgroundInternet hospitals, online health communities, and other digital health APPs have brought many changes to people’s lives. However, digital health resources are experiencing low continuance intention due to many factors, including information ...
Chengcheng Fei, Haixia Zhou, Wei Wu, Longyuan Jiang, Yuanqi Xu, Haiyan Yu   +5 more
doaj   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Starting up user-focused monitoring projects: trust and conflicting expectations in user involvement practices

Nordic Social Work Research
User-focused monitoring (UFM) is an emerging method for user involvement and quality development in the Swedish mental health sector. It involves people with lived experience conducting a systematized evaluation of a mental health service or support ...
Hilda Näslund, Katarina Grim, Urban Markström   +2 more
doaj   +1 more source