Results 71 to 80 of about 563,218 (303)
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Outcomes focused user involvement in social work education: applying knowledge to practice [PDF]
, 2016 This paper discusses an innovative approach connecting service user and carer involvement (SUCI) in social work education to social work practice.
Bašic S. C. +19 more
core +2 more sources
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
USER INVOLVEMENT IN SOCIAL WORK EDUCATION: MACEDONIAN PERSPECTIVE
Ljetopis socijalnog rada, 2009 Involving service users and carers in the education and training of social workers is higher on the policy and practice agenda in the developed countries than ever before.
Suzana Bornarova
doaj
Frontiers in Psychiatry, 2014 Background: Increasing service user and carer involvement in mental health care planning is a key healthcare priority, but one that is difficult to achieve in practice.
Chris J Gibbons +5 more
doaj +1 more source
The UCLan Engagement and Service User Support (Comensus) project: Valuing authenticity making space for emergence. [PDF]
, 2007 Objective To develop and evaluate service user, carer and community involvement in health and social care education. Background Despite the high policy profile of involvement issues, there appear to be no published accounts of schemes that have used
Downe, Soo +5 more
core +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Parental participation in statutory child protection intervention in Scotland [PDF]
, 2016 In recent years there has been an increasing interest in understanding parental participation in the processes that characterise statutory child protection intervention.
Jackson, Sharon +2 more
core +4 more sources
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source